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    MFN2 mitofusin 2 [ Homo sapiens (human) ]

    Gene ID: 9927, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The circular RNA circSLC16A10 alleviates diabetic retinopathy by improving mitochondrial function via the miR-761-5p/MFN2 axis.

    The circular RNA circSLC16A10 alleviates diabetic retinopathy by improving mitochondrial function via the miR-761-5p/MFN2 axis.
    Lu L, Ning Y, Gu F, Lin Z, Qin Y, Feng L, Tang M, Cao Y.

    09/3/2024
    MFN2 suppresses the accumulation of lipid droplets and the progression of clear cell renal cell carcinoma.

    MFN2 suppresses the accumulation of lipid droplets and the progression of clear cell renal cell carcinoma.
    Cai Z, Luo W, Wang H, Zhu R, Yuan Y, Zhan X, Xie M, Zhuang H, Chen H, Xu Y, Li X, Liu L, Xu G., Free PMC Article

    07/8/2024
    lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression.

    lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression.
    Nie X, Fan J, Wang Y, Xie R, Chen C, Li H, Wang DW.

    07/3/2024
    Mitofusin-2 enhances cervical cancer progression through Wnt/beta-catenin signaling.

    Mitofusin-2 enhances cervical cancer progression through Wnt/β-catenin signaling.
    Ahn SY., Free PMC Article

    05/24/2024
    Declined circular RNA mitofusin 2 constrains the deterioration of Wilms tumor via modulating microRNA-372-3p/transforming growth factor-beta receptor type 2 axis.

    Declined circular RNA mitofusin 2 constrains the deterioration of Wilms tumor via modulating microRNA-372-3p/transforming growth factor-β receptor type 2 axis.
    Xiao M, Pu X, Tong W, Xiao X.

    03/14/2024
    Evaluation of the role of mitofusin-1 and mitofusin-2 in periodontal disease.

    Evaluation of the role of mitofusin-1 and mitofusin-2 in periodontal disease.
    Kırmızıgül ÖA, Sabanci A, Dişli F, Yıldız S, Milward MR, Aral K.

    02/2/2024
    MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion.

    MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion.
    Goldman A, Mullokandov M, Zaltsman Y, Regev L, Levin-Zaidman S, Gross A., Free PMC Article

    01/29/2024
    Clinicopathologic features of two unrelated autopsied patients with Charcot-Marie-Tooth disease carrying MFN2 gene mutation.

    Clinicopathologic features of two unrelated autopsied patients with Charcot-Marie-Tooth disease carrying MFN2 gene mutation.
    Hayashi H, Saito R, Tanaka H, Hara N, Koide S, Yonemochi Y, Ozawa T, Hokari M, Toyoshima Y, Miyashita A, Onodera O, Okamoto K, Ikeuchi T, Nakajima T, Kakita A., Free PMC Article

    01/3/2024
    CMT2A-linked MFN2 mutation, T206I promotes mitochondrial hyperfusion and predisposes cells towards mitophagy.

    CMT2A-linked MFN2 mutation, T206I promotes mitochondrial hyperfusion and predisposes cells towards mitophagy.
    Das R, Maity S, Das P, Kamal IM, Chakrabarti S, Chakrabarti O.

    01/3/2024
    Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease.

    Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease.
    Li C, Liu Q, Chang Q, Xie M, Weng J, Wang X, Li M, Chen J, Huang Y, Yang X, Wang K, Zhang N, Chung KF, Adcock IM, Zhang H, Li F., Free PMC Article

    01/3/2024
    Homozygous Mutations in GDAP1 and MFN2 Genes Resulted in Autosomal Recessive Forms of Charcot-Marie-Tooth Disease in Consanguineous Pakistani Families.

    Homozygous Mutations in GDAP1 and MFN2 Genes Resulted in Autosomal Recessive Forms of Charcot-Marie-Tooth Disease in Consanguineous Pakistani Families.
    Asif M, Chiou CC, Hussain MF, Hussain M, Sajid Z, Gulsher M, Raheem A, Khan A, Nasreen N, Kloczkowski A, Hassan M, Iqbal F, Chen CC.,

    11/18/2023
    DIAPH1-MFN2 interaction regulates mitochondria-SR/ER contact and modulates ischemic/hypoxic stress.

    DIAPH1-MFN2 interaction regulates mitochondria-SR/ER contact and modulates ischemic/hypoxic stress.
    Yepuri G, Ramirez LM, Theophall GG, Reverdatto SV, Quadri N, Hasan SN, Bu L, Thiagarajan D, Wilson R, Díez RL, Gugger PF, Mangar K, Narula N, Katz SD, Zhou B, Li H, Stotland AB, Gottlieb RA, Schmidt AM, Shekhtman A, Ramasamy R., Free PMC Article

    11/3/2023
    A human mitofusin 2 mutation can cause mitophagic cardiomyopathy.

    A human mitofusin 2 mutation can cause mitophagic cardiomyopathy.
    Franco A, Li J, Kelly DP, Hershberger RE, Marian AJ, Lewis RM, Song M, Dang X, Schmidt AD, Mathyer ME, Edwards JR, Strong CG, Dorn GW., Free PMC Article

    11/3/2023
    Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8[+] T cell metabolic fitness and function in tumors.

    Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8(+) T cell metabolic fitness and function in tumors.
    Yang JF, Xing X, Luo L, Zhou XW, Feng JX, Huang KB, Liu H, Jin S, Liu YN, Zhang SH, Pan YH, Yu B, Yang JY, Cao YL, Cao Y, Yang CY, Wang Y, Zhang Y, Li J, Xia X, Kang T, Xu RH, Lan P, Luo JH, Han H, Bai F, Gao S.

    09/28/2023
    LRRK2 aggravates kidney injury through promoting MFN2 degradation and abnormal mitochondrial integrity.

    LRRK2 aggravates kidney injury through promoting MFN2 degradation and abnormal mitochondrial integrity.
    Zhang S, Qian S, Liu H, Xu D, Xia W, Duan H, Wang C, Yu S, Chen Y, Ji P, Wang S, Cui X, Wang Y, Shen H., Free PMC Article

    09/13/2023
    Mitofusin 1 overexpression rescues the abnormal mitochondrial dynamics caused by the Mitofusin 2 K357T mutation in vitro.

    Mitofusin 1 overexpression rescues the abnormal mitochondrial dynamics caused by the Mitofusin 2 K357T mutation in vitro.
    Stavropoulos F, Georgiou E, Schiza N, Bell S, Baloh RH, Kleopa KA, Sargiannidou I.

    09/8/2023
    The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases.

    The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases.
    Colpman P, Dasgupta A, Archer SL., Free PMC Article

    08/2/2023
    Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria.

    Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria.
    Naón D, Hernández-Alvarez MI, Shinjo S, Wieczor M, Ivanova S, Martins de Brito O, Quintana A, Hidalgo J, Palacín M, Aparicio P, Castellanos J, Lores L, Sebastián D, Fernández-Veledo S, Vendrell J, Joven J, Orozco M, Zorzano A, Scorrano L.

    07/10/2023
    MFN2 deficiency affects calcium homeostasis in lung adenocarcinoma cells via downregulation of UCP4.

    MFN2 deficiency affects calcium homeostasis in lung adenocarcinoma cells via downregulation of UCP4.
    Zhang J, Pan L, Zhang Q, Zhao Y, Wang W, Lin N, Zhang S, Wu Q., Free PMC Article

    06/12/2023
    Mitofusin-2: Functional switch between mitochondrial function and neurodegeneration.

    Mitofusin-2: Functional switch between mitochondrial function and neurodegeneration.
    Kulkarni PG, Mohire VM, Bhaisa PK, Joshi MM, Puranik CM, Waghmare PP, Banerjee T.

    03/14/2023
    Mitofusin 2 mutation drives cell proliferation in Charcot-Marie-Tooth 2A fibroblasts.

    Mitofusin 2 mutation drives cell proliferation in Charcot-Marie-Tooth 2A fibroblasts.
    Zanfardino P, Longo G, Amati A, Morani F, Picardi E, Girolamo F, Pafundi M, Cox SN, Manzari C, Tullo A, Doccini S, Santorelli FM, Petruzzella V.

    01/21/2023
    CircHIPK3 Regulates Vascular Smooth Muscle Cell Calcification Via the miR-106a-5p/MFN2 Axis.

    CircHIPK3 Regulates Vascular Smooth Muscle Cell Calcification Via the miR-106a-5p/MFN2 Axis.
    Zhang WB, Qi YF, Xiao ZX, Chen H, Liu SH, Li ZZ, Zeng ZF, Wu HF.

    12/17/2022
    A mitofusin 2/HIF1alpha axis sets a maturation checkpoint in regenerating skeletal muscle.

    A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle.
    Wang X, Jia Y, Zhao J, Lesner NP, Menezes CJ, Shelton SD, Venigalla SSK, Xu J, Cai C, Mishra P., Free PMC Article

    12/10/2022
    CMT2A-linked mitochondrial hyperfusion-driving mutant MFN2 perturbs ER-mitochondrial associations and Ca(2+) homeostasis.

    CMT2A-linked mitochondrial hyperfusion-driving mutant MFN2 perturbs ER-mitochondrial associations and Ca(2+) homeostasis.
    Das R, Das S, Chakrabarti S, Chakrabarti O.

    11/12/2022
    Mfn2-mediated mitochondrial fusion promotes autophagy and suppresses ovarian cancer progression by reducing ROS through AMPK/mTOR/ERK signaling.

    Mfn2-mediated mitochondrial fusion promotes autophagy and suppresses ovarian cancer progression by reducing ROS through AMPK/mTOR/ERK signaling.
    Ashraf R, Kumar S.

    11/5/2022
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