| Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics. | Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics.
Kim MH, Chang HS, Lee JU, Shim JS, Park JS, Cho YJ, Park CS., Free PMC Article | 05/14/2022 |
| Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains. | Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.
Elvers KT, Lipka-Lloyd M, Trueman RC, Bax BD, Mehellou Y. | 03/12/2022 |
| The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner. | The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.
Dhiani BA, Mehellou Y. | 03/27/2021 |
| SPAK and OSR1 kinases bind and phosphorylate the beta2-Adrenergic receptor. | SPAK and OSR1 kinases bind and phosphorylate the β(2)-Adrenergic receptor.
Elzwawi A, Grafton G, Barnes NM, Mehellou Y. | 03/20/2021 |
| High expression of OSR1 as a predictive biomarker for poor prognosis and lymph node metastasis in breast cancer. | High expression of OSR1 as a predictive biomarker for poor prognosis and lymph node metastasis in breast cancer.
Li Y, Qin J, Wu J, Dai X, Xu J. | 01/9/2021 |
| Regulation of ClC-2 activity by SPAK and OSR1. | Regulation of ClC-2 activity by SPAK and OSR1.
Warsi J, Hosseinzadeh Z, Elvira B, Bissinger R, Shumilina E, Lang F. | 11/21/2020 |
| WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. | WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.
Anselmo AN, Earnest S, Chen W, Juang YC, Kim SC, Zhao Y, Cobb MH., Free PMC Article | 11/21/2020 |
| SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels. | SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels.
Elvira B, Warsi J, Fezai M, Munoz C, Lang F. | 11/21/2020 |
| Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1. | Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1.
Fezai M, Elvira B, Borras J, Ben-Attia M, Hoseinzadeh Z, Lang F. | 11/21/2020 |
| Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1. | Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1.
Warsi J, Elvira B, Bissinger R, Shumilina E, Hosseinzadeh Z, Lang F. | 11/21/2020 |
| Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses. | Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
Vorontsova I, Lam L, Delpire E, Lim J, Donaldson P., Free PMC Article | 11/21/2020 |
| Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. | Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.
Richardson C, Sakamoto K, de los Heros P, Deak M, Campbell DG, Prescott AR, Alessi DR., Free PMC Article | 11/21/2020 |
| Structure of the OSR1 kinase, a hypertension drug target. | Structure of the OSR1 kinase, a hypertension drug target.
Villa F, Deak M, Alessi DR, van Aalten DM. | 11/21/2020 |
| Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. | Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.
Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR. | 11/21/2020 |
| Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. | Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.
Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HK, Alessi DR., Free PMC Article | 11/21/2020 |
| Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb (SLC34A2) by the Kinases SPAK and OSR1. | Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb (SLC34A2) by the Kinases SPAK and OSR1.
Fezai M, Elvira B, Warsi J, Ben-Attia M, Hosseinzadeh Z, Lang F. | 11/21/2020 |
| SPAK and OSR1 Sensitivity of Excitatory Amino Acid Transporter EAAT3. | SPAK and OSR1 Sensitivity of Excitatory Amino Acid Transporter EAAT3.
Borrás J, Salker MS, Elvira B, Warsi J, Fezai M, Hoseinzadeh Z, Lang F. | 11/21/2020 |
| Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals. | Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.
Sengupta S, Lorente-Rodríguez A, Earnest S, Stippec S, Guo X, Trudgian DC, Mirzaei H, Cobb MH., Free PMC Article | 11/21/2020 |
| Association of OSR-1 With Vascular Dysfunction and Hypertension in Polycystic Kidney Disease. | Association of OSR-1 With Vascular Dysfunction and Hypertension in Polycystic Kidney Disease.
Kocyigit I, Taheri S, Eroglu E, Zararsiz G, Sener EF, Uzun I, Imamoglu H, Mehmetbeyoglu E, Unal A, Korkmaz K, Sipahioglu MH, Oymak O, Tokgoz B. | 10/24/2020 |
| report the optimisation and expression of isotopically labelled OSR1 C-terminal domain (CTD) in E.coli and a structural model based on the sequence specific NMR assignments giving insights into the structure of apo OSR1 CTD | Sequence specific assignment and determination of OSR1 C-terminal domain structure by NMR.
AlAmri MA, Jeeves M, Mehellou Y. | 02/22/2020 |
| Increased expression of proteins STAT5B, GRB2, and OXSR1 was related to a higher probability of metastasis. Multivariate analysis demonstrated that tumor grade and STAT5B were independent prognostic factors. | Circulating Candidate Biomarkers in Giant Cell Tumors of Bone.
Conti A, Luchini A, Benassi MS, Magagnoli G, Pierini M, Piccinni-Leopardi M, Quattrini I, Pollino S, Picci P, Liotta LA, Pazzaglia L. | 04/13/2019 |
| our data show a novel role for the WNK1/OSR1/NKCC1 pathway in glioma migration | WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration.
Zhu W, Begum G, Pointer K, Clark PA, Yang SS, Lin SH, Kahle KT, Kuo JS, Sun D., Free PMC Article | 06/29/2018 |
| study identifies a separation of functions for the WNK1-activated protein kinases OSR1 and SPAK in mediating proliferation, invasion, and gene expression in endothelial cells | Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.
Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH., Free PMC Article | 06/29/2018 |
| The CCT domain directly interacts with the kinase domain to block substrate access and inhibit the domain-swapped homodimerization of the kinase domain of OSR1. | Structural and biochemical insights into the activation mechanisms of germinal center kinase OSR1.
Li C, Feng M, Shi Z, Hao Q, Song X, Wang W, Zhao Y, Jiao S, Zhou Z., Free PMC Article | 06/29/2018 |
| SPAK and OSR1 are powerful negative regulators of the excitatory glutamate transporters EAAT1 and EAAT2. | Down-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by the Kinases SPAK and OSR1.
Abousaab A, Warsi J, Elvira B, Alesutan I, Hoseinzadeh Z, Lang F. | 06/29/2018 |