| HS3ST2 expression induces the cell autonomous aggregation of tau. | HS3ST2 expression induces the cell autonomous aggregation of tau.
Huynh MB, Rebergue N, Merrick H, Gomez-Henao W, Jospin E, Biard DSF, Papy-Garcia D., Free PMC Article | 07/2/2022 |
| CpG Islands Methylation Analysis of CDH11, EphA5, and HS3ST2 Genes in Gastric Adenocarcinoma Patients. | CpG Islands Methylation Analysis of CDH11, EphA5, and HS3ST2 Genes in Gastric Adenocarcinoma Patients.
Eyvazi S, Khamaneh AM, Tarhriz V, Bandehpour M, Hejazi MS, Sadat ATE, Sepehri B. | 02/6/2021 |
| Hsa-miR-194-5p might be involved in the pathogenesis of atopic dermatitis by regulating HS3ST2 expression. | Possible role of hsa-miR-194-5p, via regulation of HS3ST2, in the pathogenesis of atopic dermatitis in children.
Meng L, Li M, Gao Z, Ren H, Chen J, Liu X, Cai Q, Jiang L, Ren X, Yu Q, Chen J, Yang L. | 06/13/2020 |
| Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesio | Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesions.
Danková Z, Braný D, Dvorská D, Ňachajová M, Fiolka R, Grendár M, Hatok J, Kubatka P, Holubeková V, Halašová E, Bielik T, Žúbor P., Free PMC Article | 02/23/2019 |
| In primary macrophages, HS3ST2 was clearly visualized at the plasma membrane. Its truncated form remained in the Golgi apparatus, meaning that the catalytic domain might support correct addressing of HS3ST2 to cell surface. HS3ST2 partly co-localized with syndecan-2 in HeLa cells and primary macrophages suggesting that this enzyme may participate in discrete processes that occur at the cell surface. | Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2) displays an unexpected subcellular localization in the plasma membrane.
Delos M, Foulquier F, Hellec C, Vicogne D, Fifre A, Carpentier M, Papy-Garcia D, Allain F, Denys A. | 08/18/2018 |
| HS3ST2 and CCNA1 genes may play important roles in HPV-induced cervical cancer and patients with specific hypermethylated genes may have a greater risk of progressing to invasive cervical cancer. | Methylation in the promoters of HS3ST2 and CCNA1 genes is associated with cervical cancer in Uygur women in Xinjiang.
Zuo Q, Zheng W, Zhang J, Pan Z, Liu Y, Long H, Fan P, Guo C, Li F, Shao R. | 08/29/2015 |
| By interacting with tau at the intracellular level, the 3-O-sulphated heparan sulphates produced by HS3ST2 might act as molecular chaperones allowing the abnormal phosphorylation of tau | HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.
Sepulveda-Diaz JE, Alavi Naini SM, Huynh MB, Ouidja MO, Yanicostas C, Chantepie S, Villares J, Lamari F, Jospin E, van Kuppevelt TH, Mensah-Nyagan AG, Raisman-Vozari R, Soussi-Yanicostas N, Papy-Garcia D., Free PMC Article | 07/25/2015 |
| HS3ST2 hypermethylation may be an independent prognostic indicator for overall survival in node-negative stage I-II NSCLC | Epigenetic inactivation of heparan sulfate (glucosamine) 3-O-sulfotransferase 2 in lung cancer and its role in tumorigenesis.
Hwang JA, Kim Y, Hong SH, Lee J, Cho YG, Han JY, Kim YH, Han J, Shim YM, Lee YS, Kim DH., Free PMC Article | 09/6/2014 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.
Ikeda M, Tomita Y, Mouri A, Koga M, Okochi T, Yoshimura R, Yamanouchi Y, Kinoshita Y, Hashimoto R, Williams HJ, Takeda M, Nakamura J, Nabeshima T, Owen MJ, O'Donovan MC, Honda H, Arinami T, Ozaki N, Iwata N. | 12/2/2009 |
| The 3OST-2 and -4 are specifically expressed in brain. | Tetrasulfated disaccharide unit in heparan sulfate: enzymatic formation and tissue distribution.
Mochizuki H, Yoshida K, Shibata Y, Kimata K., Free PMC Article | 01/21/2010 |
| 3-OST-2 and 3-OST-4 are the major neural gD-type 3-OSTs, and so are prime candidates for participating in HS-dependent neurobiologic events. | The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues.
Lawrence R, Yabe T, Hajmohammadi S, Rhodes J, McNeely M, Liu J, Lamperti ED, Toselli PA, Lech M, Spear PG, Rosenberg RD, Shworak NW., Free PMC Article | 01/21/2010 |
| These results showed that silencing of 3-OST-2 was present in a wide range of human cancersFrom the high incidence, silencing of the 3-OST-2 gene is expected to have high diagnostic, and potentially therapeutic, values. | Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers.
Miyamoto K, Asada K, Fukutomi T, Okochi E, Yagi Y, Hasegawa T, Asahara T, Sugimura T, Ushijima T. | 01/21/2010 |
| results raise the possibility of a role of 3-OST-2 in the spread of HSV-1 infection in the brain | A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread.
O'Donnell CD, Tiwari V, Oh MJ, Shukla D. | 01/21/2010 |