| Functional Characterization of Circadian Nuclear Receptors REV-ERBalpha and REV-ERBbeta in Human Osteosarcoma Cell Cultures. | Functional Characterization of Circadian Nuclear Receptors REV-ERBα and REV-ERBβ in Human Osteosarcoma Cell Cultures.
Cho H, Yun A, Kim J, Park E, Jung JW, Chung S, Son GH., Free PMC Article | 02/1/2024 |
| Novel CLOCK and NR1D2 variants in 64 sighted Japanese individuals with non-24-hour sleep-wake rhythm disorder. | Novel CLOCK and NR1D2 variants in 64 sighted Japanese individuals with non-24-hour sleep-wake rhythm disorder.
Hida A, Iida A, Ukai M, Kadotani H, Uchiyama M, Ebisawa T, Inoue Y, Kitamura S, Mishima K., Free PMC Article | 06/14/2023 |
| Human nuclear hormone receptor activity contributes to malaria parasite liver stage development. | Human nuclear hormone receptor activity contributes to malaria parasite liver stage development.
Mittal N, Davis C, McLean P, Calla J, Godinez-Macias KP, Gardner A, Healey D, Orjuela-Sanchez P, Ottilie S, Chong Y, Gibson C, Winzeler EA., Free PMC Article | 05/23/2023 |
| Role of Circadian Transcription Factor Rev-Erb in Metabolism and Tissue Fibrosis. | Role of Circadian Transcription Factor Rev-Erb in Metabolism and Tissue Fibrosis.
Raza GS, Sodum N, Kaya Y, Herzig KH., Free PMC Article | 11/19/2022 |
| RORalpha and REV-ERBalpha are Associated With Clinicopathological Parameters and are Independent Biomarkers of Prognosis in Gastric Cancer. | RORα and REV-ERBα are Associated With Clinicopathological Parameters and are Independent Biomarkers of Prognosis in Gastric Cancer.
Wang X, Jia R, Chen K, Wang J, Jiang K, Wang Z., Free PMC Article | 02/12/2022 |
| Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection. | Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection.
Tang M, Hu Z, Rao C, Chen J, Yuan S, Zhang J, Mao C, Yan J, Xia Y, Zhang M, Yue J, Xiang Y, Xie J, Mao X, Li Q., Free PMC Article | 01/22/2022 |
| Ferric heme as a CO/NO sensor in the nuclear receptor Rev-Erbss by coupling gas binding to electron transfer. | Ferric heme as a CO/NO sensor in the nuclear receptor Rev-Erbß by coupling gas binding to electron transfer.
Sarkar A, Carter EL, Harland JB, Speelman AL, Lehnert N, Ragsdale SW., Free PMC Article | 05/15/2021 |
| Determination of genetic changes of Rev-erb beta and Rev-erb alpha genes in Type 2 diabetes mellitus by next-generation sequencing. | Determination of genetic changes of Rev-erb beta and Rev-erb alpha genes in Type 2 diabetes mellitus by next-generation sequencing.
Tokat B, Kanca-Demirci D, Gul N, Satman I, Ozturk O, Ozder A, Kucukhuseyin O, Yilmaz-Aydogan H. | 10/24/2020 |
| REVIEW: Redox Regulation of Heme Oxygenase-2 and the Transcription Factor, Rev-Erb, Through Heme Regulatory Motifs | Redox Regulation of Heme Oxygenase-2 and the Transcription Factor, Rev-Erb, Through Heme Regulatory Motifs.
Fleischhacker AS, Carter EL, Ragsdale SW., Free PMC Article | 10/5/2019 |
| A GBM-promoting role of NR1D2. | Circadian regulator NR1D2 regulates glioblastoma cell proliferation and motility.
Yu M, Li W, Wang Q, Wang Y, Lu F. | 03/2/2019 |
| Rev-erbalpha regulates Cyp7a1 and cholesterol metabolism through its repression of the Lrh-1 receptor. | REV-ERBα Regulates CYP7A1 Through Repression of Liver Receptor Homolog-1.
Zhang T, Zhao M, Lu D, Wang S, Yu F, Guo L, Wen S, Wu B. | 10/20/2018 |
| Data show that miR-210 inhibits the expression of nuclear receptor subfamily 1, group D, member 2 (NR1D2), particularly in cryptorchidic tissues. | The functional and predictive roles of miR-210 in cryptorchidism.
Duan Z, Huang H, Sun F., Free PMC Article | 07/7/2018 |
| These results demonstrate the importance of the Rev-erbbeta HRM in regulating interactions with heme and NCoR1 and advance our understanding of how signaling through HRMs affects the major cellular processes of circadian rhythm maintenance and metabolism. | The heme-regulatory motif of nuclear receptor Rev-erbβ is a key mediator of heme and redox signaling in circadian rhythm maintenance and metabolism.
Carter EL, Ramirez Y, Ragsdale SW., Free PMC Article | 07/15/2017 |
| heme is involved in regulating the degradation of Rev-erbbeta in a manner consistent with its role in circadian rhythm maintenance | High Affinity Heme Binding to a Heme Regulatory Motif on the Nuclear Receptor Rev-erbβ Leads to Its Degradation and Indirectly Regulates Its Interaction with Nuclear Receptor Corepressor.
Carter EL, Gupta N, Ragsdale SW., Free PMC Article | 06/28/2016 |
| Together, the findings demonstrate an anti-inflammatory effect, downregulating of MMP-9 and CCL2 transcription, of astroglial REV-ERBs activation through HDAC3-dependent and HDAC3-independent mechanisms. | Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells.
Morioka N, Tomori M, Zhang FF, Saeki M, Hisaoka-Nakashima K, Nakata Y. | 05/7/2016 |
| REV-ERBbeta plays a role in supporting cancer cell viability when autophagy is compromised. | Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells.
De Mei C, Ercolani L, Parodi C, Veronesi M, Lo Vecchio C, Bottegoni G, Torrente E, Scarpelli R, Marotta R, Ruffili R, Mattioli M, Reggiani A, Wade M, Grimaldi B., Free PMC Article | 04/12/2016 |
| REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American. | REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American.
Garaulet M, Smith CE, Gomez-Abellán P, Ordovás-Montañés M, Lee YC, Parnell LD, Arnett DK, Ordovás JM., Free PMC Article | 11/7/2015 |
| Cobalt protoporphyrin IX (CoPP) and zinc protoporphyrin IX (ZnPP) are ligands that bind directly to the REV-ERBs. However, instead of mimicking the agonist action of heme, CoPP and ZnPP function as antagonists of REV-ERB function. | Structure of REV-ERBβ ligand-binding domain bound to a porphyrin antagonist.
Matta-Camacho E, Banerjee S, Hughes TS, Solt LA, Wang Y, Burris TP, Kojetin DJ., Free PMC Article | 10/11/2014 |
| Our results suggest that the REV-ERBalpha rs2071427 polymorphism modulates body fat mass in both adult and young people. | Impact of REV-ERB alpha gene polymorphisms on obesity phenotypes in adult and adolescent samples.
Goumidi L, Grechez A, Dumont J, Cottel D, Kafatos A, Moreno LA, Molnar D, Moschonis G, Gottrand F, Huybrechts I, Dallongeville J, Amouyel P, Delaunay F, Meirhaeghe A. | 02/22/2014 |
| oxidative stress leads to oxidation of cysteine(s), thus releasing heme from Rev-erbbeta and altering its transcriptional activity. | Thiol-disulfide redox dependence of heme binding and heme ligand switching in nuclear hormone receptor rev-erb{beta}.
Gupta N, Ragsdale SW., Free PMC Article | 03/26/2011 |
| Nuclear receptor rev-erb-{alpha} circadian gene variants have a role in response to lithium carbonate in bipolar affective disorder | Nuclear receptor rev-erb-{alpha} circadian gene variants and lithium carbonate prophylaxis in bipolar affective disorder.
Campos-de-Sousa S, Guindalini C, Tondo L, Munro J, Osborne S, Floris G, Pedrazzoli M, Tufik S, Breen G, Collier D. | 06/28/2010 |
| Rev-erbbeta modulates the apoCIII gene expression by recruiting different transcription co-activator or co-repressor. | The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter.
Wang J, Liu N, Liu Z, Li Y, Song C, Yuan H, Li YY, Zhao X, Lu H. | 01/21/2010 |
| heme regulation of REV-ERBs may link the control of metabolism and the mammalian clock | Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta.
Raghuram S, Stayrook KR, Huang P, Rogers PM, Nosie AK, McClure DB, Burris LL, Khorasanizadeh S, Burris TP, Rastinejad F., Free PMC Article | 01/21/2010 |