| PRMT6-FOXO3A ATTENUATES APOPTOSIS BY UPREGULATING PARKIN EXPRESSION IN INTESTINAL ISCHEMIA-REPERFUSION INJURY. | PRMT6-FOXO3A ATTENUATES APOPTOSIS BY UPREGULATING PARKIN EXPRESSION IN INTESTINAL ISCHEMIA-REPERFUSION INJURY.
Wu X, Zhou Y, Xu H, Zhang X, Yao L, Li J, Li X. | 05/10/2024 |
| PRMT6 deficiency or inhibition alleviates neuropathic pain by decreasing glycolysis and inflammation in microglia. | PRMT6 deficiency or inhibition alleviates neuropathic pain by decreasing glycolysis and inflammation in microglia.
Hua T, Kong E, Zhang H, Lu J, Huang K, Ding R, Wang H, Li J, Han C, Yuan H. | 04/12/2024 |
| Arginine Methylation of Integrin Alpha-4 Prevents Fibrosis Development in Alcohol-Associated Liver Disease. | Arginine Methylation of Integrin Alpha-4 Prevents Fibrosis Development in Alcohol-Associated Liver Disease.
Schonfeld M, Villar MT, Artigues A, Weinman SA, Tikhanovich I., Free PMC Article | 12/31/2022 |
| The N(6)-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6. | The N(6)-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6.
Li Z, Wang P, Li J, Xie Z, Cen S, Li M, Liu W, Ye G, Zheng G, Ma M, Wang S, Yu W, Wu Y, Shen H., Free PMC Article | 10/16/2021 |
| Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6. | Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6.
Cheng D, Gao G, Di Lorenzo A, Jayne S, Hottiger MO, Richard S, Bedford MT., Free PMC Article | 03/20/2021 |
| The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling. | The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling.
Zhang H, Han C, Li T, Li N, Cao X., Free PMC Article | 08/29/2020 |
| Loss of PPARalpha from the intestine promotes colon carcinogenesis by increasing DNMT1/PRMT6-mediated DNA methylation. | Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ., Free PMC Article | 09/28/2019 |
| It was confirmed that PRMT6 was involved in the process of adipocyte differentiation. In addition, PRMT6 interacted with, but did not methylate, PPARgamma. PRMT6 bound to the PPARresponsive regulatory element of the adipocyte Protein 2 (aP2) promoter in conjunction with PPARgamma and generated the repressive epigenetic mark arginine 2 on histone H3 asymmetric dimethylation, which suppressed aP2 gene expression. | Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator‑activated receptor γ activity.
Hwang JW, So YS, Bae GU, Kim SN, Kim YK. | 08/24/2019 |
| Six crystal structures of PRMT6 from Mus musculus, solved and refined at 1.34 A for the highest resolution structure are described. | Functional insights from high resolution structures of mouse protein arginine methyltransferase 6.
Bonnefond L, Stojko J, Mailliot J, Troffer-Charlier N, Cura V, Wurtz JM, Cianférani S, Cavarelli J. | 05/28/2016 |
| Prmt6 is important for embryonic stem cell pluripotency and self-renewal. | Protein arginine methyltransferase 6 regulates embryonic stem cell identity.
Lee YH, Ma H, Tan TZ, Ng SS, Soong R, Mori S, Fu XY, Zernicka-Goetz M, Wu Q., Free PMC Article | 02/9/2013 |
| The findings define a new regulator of p53 transcriptional regulation and define a role for PRMT6 and arginine methylation in cellular senescence. | Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor.
Neault M, Mallette FA, Vogel G, Michaud-Levesque J, Richard S., Free PMC Article | 01/26/2013 |