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    ADRA1B adrenoceptor alpha 1B [ Homo sapiens (human) ]

    Gene ID: 147, updated on 28-Oct-2024

    Summary

    Official Symbol
    ADRA1Bprovided by HGNC
    Official Full Name
    adrenoceptor alpha 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:278
    See related
    Ensembl:ENSG00000170214 MIM:104220; AllianceGenome:HGNC:278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADRA1; ALPHA1BAR
    Summary
    Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in spleen (RPKM 2.0), brain (RPKM 1.2) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADRA1B in Genome Data Viewer
    Location:
    5q33.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (159865086..159989205)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (160393464..160517778)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159343489..159400019)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377687 Neighboring gene uncharacterized LOC105377688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159200044-159200558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159200559-159201071 Neighboring gene NANOG hESC enhancer GRCh37_chr5:159201487-159201994 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:159205410-159206609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16573 Neighboring gene long intergenic non-protein coding RNA 1847 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:159300789-159301988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159343446-159344062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159344063-159344679 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159355809-159356308 Neighboring gene uncharacterized LOC101927790 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 40 Neighboring gene MPRA-validated peak5555 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159435885-159436780 Neighboring gene uncharacterized LOC124901124 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:159455528-159455695 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:159469604-159470298 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:159470299-159470993 Neighboring gene tetratricopeptide repeat domain 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159487609-159488120 Neighboring gene MPRA-validated peak5557 silencer Neighboring gene PWWP domain containing 2A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:159507098-159508004 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159508005-159508910 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:159513521-159513688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23555 Neighboring gene MPRA-validated peak5558 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16575 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159546009-159546508

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha1-adrenergic receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    alpha-1B adrenergic receptor
    Names
    adrenergic, alpha-1B-, receptor
    alpha-1B adrenoceptor
    alpha-1B adrenoreceptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000679.4NP_000670.1  alpha-1B adrenergic receptor

      See identical proteins and their annotated locations for NP_000670.1

      Status: REVIEWED

      Source sequence(s)
      AC011343, AC068657, BQ576306, U03865
      Consensus CDS
      CCDS4347.1
      UniProtKB/Swiss-Prot
      B0LPE1, P35368
      Related
      ENSP00000306662.3, ENST00000306675.5
      Conserved Domains (2) summary
      pfam00001
      Location:62348
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56363
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      159865086..159989205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416776.1XP_047272732.1  alpha-1B adrenergic receptor isoform X1

    2. XM_011534435.2XP_011532737.1  alpha-1B adrenergic receptor isoform X1

      Conserved Domains (2) summary
      pfam00001
      Location:62384
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:57181
      7tm_4; Olfactory receptor
    3. XM_006714821.4XP_006714884.1  alpha-1B adrenergic receptor isoform X5

      Conserved Domains (2) summary
      pfam00001
      Location:62324
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:57181
      7tm_4; Olfactory receptor
    4. XM_005265819.3XP_005265876.1  alpha-1B adrenergic receptor isoform X6

      Conserved Domains (2) summary
      pfam00001
      Location:62314
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:57181
      7tm_4; Olfactory receptor
    5. XM_011534437.3XP_011532739.1  alpha-1B adrenergic receptor isoform X2

      Conserved Domains (2) summary
      pfam00001
      Location:62312
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:57181
      7tm_4; Olfactory receptor
    6. XM_005265818.4XP_005265875.1  alpha-1B adrenergic receptor isoform X4

      Conserved Domains (2) summary
      pfam00001
      Location:62318
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:57181
      7tm_4; Olfactory receptor
    7. XM_011534438.3XP_011532740.1  alpha-1B adrenergic receptor isoform X3

      Conserved Domains (2) summary
      pfam00001
      Location:62312
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:57181
      7tm_4; Olfactory receptor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      160393464..160517778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351711.1XP_054207686.1  alpha-1B adrenergic receptor isoform X1

    2. XM_054351709.1XP_054207684.1  alpha-1B adrenergic receptor isoform X1

    3. XM_054351710.1XP_054207685.1  alpha-1B adrenergic receptor isoform X1

    4. XM_054351715.1XP_054207690.1  alpha-1B adrenergic receptor isoform X5

    5. XM_054351716.1XP_054207691.1  alpha-1B adrenergic receptor isoform X6

    6. XM_054351712.1XP_054207687.1  alpha-1B adrenergic receptor isoform X2

    7. XM_054351714.1XP_054207689.1  alpha-1B adrenergic receptor isoform X4

    8. XM_054351713.1XP_054207688.1  alpha-1B adrenergic receptor isoform X3