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    ST7 suppression of tumorigenicity 7 [ Homo sapiens (human) ]

    Gene ID: 7982, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ST7provided by HGNC
    Official Full Name
    suppression of tumorigenicity 7provided by HGNC
    Primary source
    HGNC:HGNC:11351
    See related
    Ensembl:ENSG00000004866 MIM:600833; AllianceGenome:HGNC:11351
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HELG; RAY1; SEN4; TSG7; ETS7q; FAM4A; FAM4A1
    Summary
    The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 11.1), lung (RPKM 10.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ST7 in Genome Data Viewer
    Location:
    7q31.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (116953501..117230176)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (118268670..118545512)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116593555..116870230)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit alpha 2 Neighboring gene uncharacterized LOC124901857 Neighboring gene greater CFTR locus negative regulatory element CR9 Neighboring gene Sharpr-MPRA regulatory region 2110 Neighboring gene uncharacterized LOC105375465 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18564 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:116593626-116594549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18567 Neighboring gene RNA, 5S ribosomal pseudogene 239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18568 Neighboring gene NANOG hESC enhancer GRCh37_chr7:116609424-116609981 Neighboring gene ST7 antisense RNA 1 Neighboring gene ST7 overlapping transcript 4 Neighboring gene tropomyosin 3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18569 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:116659304-116660503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26542 Neighboring gene microRNA 6132 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:116716803-116717302 Neighboring gene greater CFTR locus negative regulatory element NR4 Neighboring gene uncharacterized LOC124901732 Neighboring gene ST7 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26543 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:116794856-116795649 Neighboring gene greater CFTR locus negative regulatory element CR10 Neighboring gene greater CFTR locus negative regulatory element CR11 Neighboring gene ST7 overlapping transcript 3 Neighboring gene uncharacterized LOC105375466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26545 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 like 2 pseudogene Neighboring gene MT-ND2 pseudogene 37

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene. Zenklusen JC, et al. Oncogene, 1995 Jul 20. PMID 7624150
    2. Localization and characterization of ST7 in cancer. Charong N, et al. J Cancer Res Clin Oncol, 2011 Jan. PMID 20238225
    3. Distinguishing protein-coding from non-coding RNAs through support vector machines. Liu J, et al. PLoS Genet, 2006 Apr. PMID 16683024, Free PMC Article
    4. Mutational analysis of the ST7 gene in human myeloid tumor cell lines. Sivasundaram K, et al. Oncol Rep, 2003 Nov-Dec. PMID 14534688
    5. An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma. Wang S, et al. Oncogene, 2003 Jan 23. PMID 12545169

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inflammation-dependent overexpression of c-Myc enhances CRL4(DCAF4) E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.
      Title: Inflammation-dependent overexpression of c-Myc enhances CRL4(DCAF4) E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.
    2. The tumor suppressor ST7 is a key gene silenced by PRMT5.
      Title: Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma.
    3. ST7 mediates tumor suppression through the regulation of the genes involved in maintaining the cellular structure of the cell and involved in oncogenic pathways
      Title: Localization and characterization of ST7 in cancer.
    4. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    7. The ST7 gene is not a primary target of inactivation in most human cancers with loss of heterozygosity at 7q31.1-q31.2.
      Title: Absence of ST7 gene alterations in human cancer.
    8. Mutational analysis of ST7 in a wide range of cell lines and primary epithelial cancer failed to detect mutations at this locus, with the exception of 1 missense change in a breast cancer cell line.
      Title: Lack of mutations within ST7 gene in tumour-derived cell lines and primary epithelial tumours.
    9. somatic mutations of ST7 do not commonly contribute to the molecular pathogenesis of human malignant myeloid tumors
      Title: Mutational analysis of the ST7 gene in human myeloid tumor cell lines.
    10. ST7 gene may not be the target gene of inactivation at 7q31 site in gastric carcinoma.
      Title: Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp762O2113

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of tumorigenicity 7 protein
    Names
    family with sequence similarity 4, subfamily A, member 1
    suppression of tumorigenicity 7 (breast)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047088.1 RefSeqGene

      Range
      5175..281850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001369598.1 → NP_001356527.1  suppressor of tumorigenicity 7 protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      Consensus CDS
      CCDS94182.1
      UniProtKB/TrEMBL
      A8K8K7, H7BXS2
      Related
      ENSP00000325673.3, ENST00000323984.8
      Conserved Domains (1) summary
      pfam04184
      Location:19 → 576
      ST7; ST7 protein

    2. NM_001369599.1 → NP_001356528.1  suppressor of tumorigenicity 7 protein isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      Consensus CDS
      CCDS94185.1
      UniProtKB/TrEMBL
      A8K8K7, B7Z4L1
      Related
      ENSP00000377093.4, ENST00000393447.8
      Conserved Domains (1) summary
      cd11557
      Location:11 → 498
      ST7; Suppression of tumorigenicity 7

    3. NM_001369600.1 → NP_001356529.1  suppressor of tumorigenicity 7 protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      Consensus CDS
      CCDS94186.1
      UniProtKB/TrEMBL
      A8K8K7, G3XAH9
      Related
      ENSP00000377090.3, ENST00000393444.7
      Conserved Domains (1) summary
      cd11557
      Location:11 → 475
      ST7; Suppression of tumorigenicity 7

    4. NM_001369601.1 → NP_001356530.1  suppressor of tumorigenicity 7 protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      Consensus CDS
      CCDS94181.1
      UniProtKB/TrEMBL
      A8K8K7, E7EPD9
      Related
      ENSP00000377095.1, ENST00000393449.5
      Conserved Domains (1) summary
      pfam04184
      Location:19 → 571
      ST7; ST7 protein

    5. NM_001369602.1 → NP_001356531.1  suppressor of tumorigenicity 7 protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      Consensus CDS
      CCDS94183.1
      UniProtKB/TrEMBL
      A8K8K7, B7Z4U3
      Related
      ENSP00000411118.1, ENST00000432298.5
      Conserved Domains (1) summary
      cd11557
      Location:8 → 495
      ST7; Suppression of tumorigenicity 7

    6. NM_001369603.1 → NP_001356532.1  suppressor of tumorigenicity 7 protein isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      Consensus CDS
      CCDS94184.1
      UniProtKB/TrEMBL
      A8K8K7, E7EPW5
      Related
      ENSP00000414031.1, ENST00000422922.5
      Conserved Domains (1) summary
      cd11557
      Location:8 → 472
      ST7; Suppression of tumorigenicity 7

    7. NM_001369604.1 → NP_001356533.1  suppressor of tumorigenicity 7 protein isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC106873
      UniProtKB/TrEMBL
      B7Z573
      Conserved Domains (1) summary
      pfam04184
      Location:19 → 525
      ST7; ST7 protein

    8. NM_001369606.1 → NP_001356535.1  suppressor of tumorigenicity 7 protein isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      UniProtKB/TrEMBL
      A8K8K7
      Related
      ENSP00000377089.1, ENST00000393443.5
      Conserved Domains (1) summary
      cd11557
      Location:4 → 491
      ST7; Suppression of tumorigenicity 7

    9. NM_001369607.1 → NP_001356536.1  suppressor of tumorigenicity 7 protein isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      UniProtKB/TrEMBL
      A8K8K7
      Conserved Domains (1) summary
      cd11557
      Location:4 → 468
      ST7; Suppression of tumorigenicity 7

    10. NM_018412.4 → NP_060882.2  suppressor of tumorigenicity 7 protein isoform 5

      See identical proteins and their annotated locations for NP_060882.2

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      Consensus CDS
      CCDS5769.1
      UniProtKB/TrEMBL
      A8K8K7
      Related
      ENSP00000377097.3, ENST00000393451.7
      Conserved Domains (1) summary
      pfam04184
      Location:19 → 553
      ST7; ST7 protein

    11. NM_021908.3 → NP_068708.1  suppressor of tumorigenicity 7 protein isoform 8

      See identical proteins and their annotated locations for NP_068708.1

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC106873
      Consensus CDS
      CCDS5770.1
      UniProtKB/Swiss-Prot
      A4D0V2, Q5CZ72, Q7LE31, Q7LE32, Q8NA32, Q8NEJ8, Q8TDI9, Q9BWX3, Q9BWX4, Q9NRC1, Q9NRC2, Q9NXZ7
      UniProtKB/TrEMBL
      B7Z573, X5DRA0
      Related
      ENSP00000265437.5, ENST00000265437.9
      Conserved Domains (1) summary
      pfam04184
      Location:19 → 548
      ST7; ST7 protein

    RNA

    1. NR_161418.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873, HY033462

    2. NR_161419.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873, HY033462

    3. NR_161420.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873, HY033462

    4. NR_161421.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873, HY033462

    5. NR_161422.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873

    6. NR_161423.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      116953501..117230176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      118268670..118545512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NRC1.1 GenPept UniProtKB/Swiss-Prot:Q9NRC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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