FOXM1 forkhead box M1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FOXM1provided by HGNC
Official Full Name: forkhead box M1provided by HGNC
Primary source: HGNC:HGNC:3818
See related: Ensembl:ENSG00000111206 MIM:602341; AllianceGenome:HGNC:3818
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MPP2; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11; TRIDENT; MPHOSPH2
Summary: The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Expression: Broad expression in testis (RPKM 16.1), bone marrow (RPKM 11.2) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p13.33

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (2857680..2877174, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (2863691..2883185, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (2966846..2986340, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIRT2 deacetylates and decreases the expression of FOXM1 in colon cancer.
Title: SIRT2 deacetylates and decreases the expression of FOXM1 in colon cancer.
FOXM1 transcriptional regulation.
Title: FOXM1 transcriptional regulation.
USP22 is required for human endometrial stromal cell proliferation and decidualization by deubiquitinating FoxM1.
Title: USP22 is required for human endometrial stromal cell proliferation and decidualization by deubiquitinating FoxM1.
The RNA-binding protein IGF2BP1 regulates stability of mRNA transcribed from FOXM1 target genes in hypermitotic meningiomas.
Title: The RNA-binding protein IGF2BP1 regulates stability of mRNA transcribed from FOXM1 target genes in hypermitotic meningiomas.
Biochemical role of FOXM1-dependent histone linker H1B in human epidermal stem cells.
Title: Biochemical role of FOXM1-dependent histone linker H1B in human epidermal stem cells.
Hypermethylation and low expression of FOXM1 predisposes women to unexplained recurrent miscarriage by impairing trophoblast stem cell proliferation.
Title: Hypermethylation and low expression of FOXM1 predisposes women to unexplained recurrent miscarriage by impairing trophoblast stem cell proliferation.
KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A modification to promote aerobic glycolysis and tumorigenesis in multiple myeloma.
Title: KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A modification to promote aerobic glycolysis and tumorigenesis in multiple myeloma.
CDCA5 accelerates progression of breast cancer by promoting the binding of E2F1 and FOXM1.
Title: CDCA5 accelerates progression of breast cancer by promoting the binding of E2F1 and FOXM1.
METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib resistance by inhibiting PTPN13 expression.
Title: METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib resistance by inhibiting PTPN13 expression.
YTHDC1-dependent m6A modification modulated FOXM1 promotes glycolysis and tumor progression through CENPA in triple-negative breast cancer.
Title: YTHDC1-dependent m6A modification modulated FOXM1 promotes glycolysis and tumor progression through CENPA in triple-negative breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (623)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH45038 (e-PCR)
- UniSTS:90890

D12S1971 (e-PCR)
- UniSTS:26636

STS-T90364 (e-PCR)
- UniSTS:47537

SHGC-30387 (e-PCR)
- UniSTS:43701

RH39759 (e-PCR)
- UniSTS:89598

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in G2/M transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stress-activated MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell population proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: forkhead box protein M1

Names: Forkhead, drosophila, homolog-like 16; HNF-3/fork-head homolog 11; M-phase phosphoprotein 2; MPM-2 reactive phosphoprotein 2; forkhead box M1-D; forkhead-related protein FKHL16; hepatocyte nuclear factor 3 forkhead homolog 11; transcription factor Trident; winged-helix factor from INS-1 cells

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029590.2 RefSeqGene

Range

4982..24476

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001243088.2 → NP_001230017.1 forkhead box protein M1 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses two alternate in-frame splice junctions compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC005841, AC005911

Consensus CDS

CCDS76506.1

UniProtKB/TrEMBL

A0A0D9SFF0

Related

ENSP00000486536.1, ENST00000627656.2

Conserved Domains (1) summary

cd00059
Location:235 → 310

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
NM_001243089.2 → NP_001230018.1 forkhead box protein M1 isoform 5

See identical proteins and their annotated locations for NP_001230018.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two alternate in-frame exons and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC005841, AC005911

UniProtKB/TrEMBL

A8K591

Conserved Domains (1) summary

cd00059
Location:235 → 310

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
NM_001413925.1 → NP_001400854.1 forkhead box protein M1 isoform 6

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413926.1 → NP_001400855.1 forkhead box protein M1 isoform 7

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413927.1 → NP_001400856.1 forkhead box protein M1 isoform 8

Status: REVIEWED

Source sequence(s)

AC005841, AC005911

UniProtKB/TrEMBL

A0A2P9DTZ0
NM_001413928.1 → NP_001400857.1 forkhead box protein M1 isoform 9

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413929.1 → NP_001400858.1 forkhead box protein M1 isoform 10

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413930.1 → NP_001400859.1 forkhead box protein M1 isoform 11

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413931.1 → NP_001400860.1 forkhead box protein M1 isoform 12

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413932.1 → NP_001400861.1 forkhead box protein M1 isoform 13

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413933.1 → NP_001400862.1 forkhead box protein M1 isoform 14

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413934.1 → NP_001400863.1 forkhead box protein M1 isoform 15

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413935.1 → NP_001400864.1 forkhead box protein M1 isoform 16

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413936.1 → NP_001400865.1 forkhead box protein M1 isoform 17

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413937.1 → NP_001400866.1 forkhead box protein M1 isoform 18

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413938.1 → NP_001400867.1 forkhead box protein M1 isoform 19

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413939.1 → NP_001400868.1 forkhead box protein M1 isoform 20

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413940.1 → NP_001400869.1 forkhead box protein M1 isoform 21

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413941.1 → NP_001400870.1 forkhead box protein M1 isoform 22

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413942.1 → NP_001400871.1 forkhead box protein M1 isoform 23

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_001413943.1 → NP_001400872.1 forkhead box protein M1 isoform 24

Status: REVIEWED

Source sequence(s)

AC005841, AC005911
NM_021953.4 → NP_068772.2 forkhead box protein M1 isoform 2

See identical proteins and their annotated locations for NP_068772.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC005841, AC005911

Consensus CDS

CCDS8515.1

UniProtKB/Swiss-Prot

O43258, O43259, O43260, Q08050, Q4ZGG7, Q9BRL2

UniProtKB/TrEMBL

Q53Y49

Related

ENSP00000352901.4, ENST00000359843.8

Conserved Domains (2) summary

cd00059
Location:236 → 311

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

cl28033
Location:402 → 711

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
NM_202002.3 → NP_973731.1 forkhead box protein M1 isoform 1

See identical proteins and their annotated locations for NP_973731.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC005841, AC005911

Consensus CDS

CCDS8516.1

UniProtKB/TrEMBL

A0A2P9DTZ8

Related

ENSP00000342307.2, ENST00000342628.6

Conserved Domains (2) summary

cd00059
Location:236 → 311

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

cl28033
Location:504 → 749

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
NM_202003.3 → NP_973732.1 forkhead box protein M1 isoform 3

See identical proteins and their annotated locations for NP_973732.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC005841, AC005911

Consensus CDS

CCDS8517.1

UniProtKB/TrEMBL

A0A2P9DTZ1

Related

ENSP00000354492.3, ENST00000361953.7

Conserved Domains (1) summary

cd00059
Location:236 → 311

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

2857680..2877174 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047428550.1 → XP_047284506.1 forkhead box protein M1 isoform X4
XM_047428547.1 → XP_047284503.1 forkhead box protein M1 isoform X2
XM_047428549.1 → XP_047284505.1 forkhead box protein M1 isoform X3
XM_011520932.2 → XP_011519234.1 forkhead box protein M1 isoform X1

Conserved Domains (1) summary

cd00059
Location:236 → 311

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...