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    OASL 2'-5'-oligoadenylate synthetase like [ Homo sapiens (human) ]

    Gene ID: 8638, updated on 28-Oct-2024

    Summary

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    Official Symbol
    OASLprovided by HGNC
    Official Full Name
    2'-5'-oligoadenylate synthetase likeprovided by HGNC
    Primary source
    HGNC:HGNC:8090
    See related
    Ensembl:ENSG00000135114 MIM:603281; AllianceGenome:HGNC:8090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OASL1; OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASL
    Summary
    Enables DNA binding activity and double-stranded RNA binding activity. Involved in several processes, including interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; and positive regulation of RIG-I signaling pathway. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in bone marrow (RPKM 19.8), stomach (RPKM 11.1) and 13 other tissues See more
    Orthologs
    all
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    Genomic context

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    See OASL in Genome Data Viewer
    Location:
    12q24.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (121017761..121039246, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (121007355..121028848, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121455564..121477049, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:121410688-121411215 Neighboring gene HNF1A antisense RNA 1 Neighboring gene HNF1 homeobox A Neighboring gene chromosome 12 open reading frame 43 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121453469-121453984 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121454193-121454386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121476213-121476714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121476715-121477214 Neighboring gene Sharpr-MPRA regulatory region 13012 Neighboring gene uncharacterized LOC105378258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7156 Neighboring gene 2'-5' oligoadenylate synthetase like 2, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121530887-121531388 Neighboring gene uncharacterized LOC105370031 Neighboring gene small nucleolar RNA SNORA70

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling. Ibsen MS, et al. Nucleic Acids Res, 2015 May 26. PMID 25925578, Free PMC Article
    2. Selective inhibition of the dnase activity of the recBC enzyme by the DNA binding protein from Escherichia coli. Mackay V, et al. J Biol Chem, 1976 Jun 25. PMID 776974
    3. 2'-5'-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1. Dhar J, et al. J Virol, 2015 Oct. PMID 26178980, Free PMC Article
    4. Identification of OASL d, a splice variant of human OASL, with antiviral activity. Guo X, et al. Int J Biochem Cell Biol, 2012 Jul. PMID 22531715
    5. Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C. Su X, et al. J Hepatol, 2008 Aug. PMID 18571276, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Peptidase inhibitor 16 promotes proliferation of pancreatic ductal adenocarcinoma cells through OASL signaling.
      Title: Peptidase inhibitor 16 promotes proliferation of pancreatic ductal adenocarcinoma cells through OASL signaling.
    2. OASL regulates pro-inflammatory mediators such as cytokines and chemokines which suppress intracellular mycobacterial growth and survival.
      Title: 2'-5'-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion.
    3. these resulta define distinct mechanisms by which OASL differentially regulates host IFN responses during RNA and DNA virus infection and identify OASL as a negative-feedback regulator of cGAS
      Title: Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production.
    4. These data uncover a promycobacterial role for STING-dependent OASL production during Mycobacterium leprae infection that directs the host immune response toward a niche that permits survival of the pathogen.
      Title: STING-Dependent 2'-5' Oligoadenylate Synthetase-Like Production Is Required for Intracellular Mycobacterium leprae Survival.
    5. OASL acts as a cellular antiviral protein and RSV NS1 suppresses this function to evade cellular innate immunity and allow virus growth.
      Title: 2'-5'-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1.
    6. Primary mononuclear cells from patients with systemic sclerosis have increased basal levels of OASL and OAS2 genes.
      Title: Differential upregulation of human 2'5'OAS genes on systemic sclerosis: Detection of increased basal levels of OASL and OAS2 genes through a qPCR based assay.
    7. these findings show a mechanism by which human OASL contributes to host antiviral responses by enhancing RIG-I activation.
      Title: Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.
    8. we propose that VSV treatment combined with the selective regulation of genes such as STAT1 and OASL2 will improve therapeutic outcomes for CUG2-overexpressing tumors
      Title: Cancer upregulated gene 2, a novel oncogene, confers resistance to oncolytic vesicular stomatitis virus through STAT1-OASL2 signaling.
    9. variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
      Title: Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
    10. The pronounced difference in gene regulation between the OASL gene agrees with a functional difference between these genes, which must exist as a consequence of the lack of the 2-5A synthetase activity of the OASL protein.
      Title: Differential regulation of the OASL and OAS1 genes in response to viral infections.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
    EBI GWAS Catalog
    Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
    EBI GWAS Catalog
    Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
    EBI GWAS Catalog
    New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis.
    EBI GWAS Catalog
    Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of 2'-5'-oligoadenylate synthetase-like (OASL) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 and the viral protein Tat modulate the expression of 2'-5'-oligoadenylate synthetase-like (OASL; p59-OASL) in immature dendritic cells and monocyte-derived macrophages PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of OASL in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables 2'-5'-oligoadenylate synthetase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear thyroid hormone receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-27-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-27-mediated signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of RIG-I signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    2'-5'-oligoadenylate synthase-like protein
    Names
    2'-5'-OAS-RP
    2'-5'-OAS-related protein
    59 kDa 2'-5'-oligoadenylate synthase-like protein
    59 kDa 2'-5'-oligoadenylate synthetase-like protein
    TR-interacting protein 14
    thyroid receptor-interacting protein 14

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261825.2 → NP_001248754.1  2'-5'-oligoadenylate synthase-like protein isoform c

      See identical proteins and their annotated locations for NP_001248754.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC079602
      Consensus CDS
      CCDS73536.1
      UniProtKB/Swiss-Prot
      Q15646
      Related
      ENSP00000479512.1, ENST00000620239.6
      Conserved Domains (5) summary
      cd05400
      Location:29 → 212
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      smart00213
      Location:304 → 372
      UBQ; Ubiquitin homologues
      pfam00240
      Location:309 → 375
      ubiquitin; Ubiquitin family
      pfam10421
      Location:167 → 219
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
      cl00155
      Location:224 → 303
      UBQ; Ubiquitin-like proteins

    2. NM_001395418.1 → NP_001382347.1  2'-5'-oligoadenylate synthase-like protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC079602
      Consensus CDS
      CCDS9212.1
      Related
      ENSP00000444127.2, ENST00000543677.2
      Conserved Domains (2) summary
      cd05400
      Location:29 → 212
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:168 → 219
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    3. NM_001395419.1 → NP_001382348.1  2'-5'-oligoadenylate synthase-like protein isoform d

      Status: VALIDATED

      Source sequence(s)
      AC079602
      Consensus CDS
      CCDS91762.1
      UniProtKB/TrEMBL
      A0A7P0T9H8, A0A7P0TB39
      Related
      ENSP00000505685.1, ENST00000680620.1
      Conserved Domains (2) summary
      cd05400
      Location:29 → 212
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:168 → 349
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    4. NM_003733.4 → NP_003724.1  2'-5'-oligoadenylate synthase-like protein isoform a

      See identical proteins and their annotated locations for NP_003724.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC079602
      Consensus CDS
      CCDS9211.1
      UniProtKB/Swiss-Prot
      B2RAZ2, I1YDD2, O75686, Q15646, Q17R95, Q9Y6K6, Q9Y6K7
      UniProtKB/TrEMBL
      B3KN79
      Related
      ENSP00000257570.4, ENST00000257570.10
      Conserved Domains (4) summary
      cd05400
      Location:29 → 212
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      cd01811
      Location:354 → 433
      OASL_repeat1; 2'-5' oligoadenylate synthetase-like protein, repeat 1 of 2
      pfam00240
      Location:436 → 506
      ubiquitin; Ubiquitin family
      pfam10421
      Location:168 → 351
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    5. NM_198213.3 → NP_937856.1  2'-5'-oligoadenylate synthase-like protein isoform b

      See identical proteins and their annotated locations for NP_937856.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC079602
      Consensus CDS
      CCDS9212.1
      UniProtKB/Swiss-Prot
      Q15646
      Related
      ENSP00000341125.5, ENST00000339275.10
      Conserved Domains (2) summary
      cd05400
      Location:29 → 212
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:168 → 219
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      121017761..121039246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429803.1 → XP_047285759.1  2'-5'-oligoadenylate synthase-like protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      121007355..121028848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373702.1 → XP_054229677.1  2'-5'-oligoadenylate synthase-like protein isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15646.2 GenPept UniProtKB/Swiss-Prot:Q15646

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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