BAG2 BAG cochaperone 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: BAG2provided by HGNC
Official Full Name: BAG cochaperone 2provided by HGNC
Primary source: HGNC:HGNC:938
See related: Ensembl:ENSG00000112208 MIM:603882; AllianceGenome:HGNC:938
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BAG-2; dJ417I1.2
Summary: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Expression: Broad expression in endometrium (RPKM 20.1), urinary bladder (RPKM 13.7) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p12.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (57172326..57189833)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (57011351..57028858)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (57037124..57054631)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma.
Title: Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma.
BAG2 drives chemoresistance of breast cancer by exacerbating mutant p53 aggregate.
Title: BAG2 drives chemoresistance of breast cancer by exacerbating mutant p53 aggregate.
BAG2 prevents Tau hyperphosphorylation and increases p62/SQSTM1 in cell models of neurodegeneration.
Title: BAG2 prevents Tau hyperphosphorylation and increases p62/SQSTM1 in cell models of neurodegeneration.
c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitro.
Title: c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitro.
Helicobacter pylori Targets in AGS Human Gastric Adenocarcinoma: In Situ Proteomic Profiling and Systematic Analysis.
Title: Helicobacter pylori Targets in AGS Human Gastric Adenocarcinoma: In Situ Proteomic Profiling and Systematic Analysis.
Bcl-2 Associated Athanogene 2 (BAG2) is Associated With Progression and Prognosis of Hepatocellular Carcinoma: A Bioinformatics-Based Analysis.
Title: Bcl-2 Associated Athanogene 2 (BAG2) is Associated With Progression and Prognosis of Hepatocellular Carcinoma: A Bioinformatics-Based Analysis.
Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease.
Title: Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease.
LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2.
Title: LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2.
High-regulated BAG2 is related to poor prognosis and could promote proliferation, invasion and migration of oral squamous cell carcinomas
Title: Over-expression of Bcl2-associated athanogene 2 in oral cancer promotes cellular proliferation and is associated with poor prognosis.
the nucleotide exchange factor (NEF) Bag2 stimulates SV40 release from Hsc70, thereby enabling successful virus arrival at the cytosol, which leads to infection. Hsp105, another NEF of Hsc70, displays a function overlapping that of Bag2, underscoring the importance of this release reaction.
Title: Bag2 Is a Component of a Cytosolic Extraction Machinery That Promotes Membrane Penetration of a Nonenveloped Virus.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-34200 (e-PCR)
- UniSTS:13073

BAG2_7951 (e-PCR)
- UniSTS:467578

RH46599 (e-PCR)
- UniSTS:91602

AL035194 (e-PCR)
- UniSTS:94700

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed
enables tau protein binding	NAS Non-traceable Author Statement more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of proteasomal protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
NOT involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within protein metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info	PubMed
colocalizes_with dendritic microtubule	ISS Inferred from Sequence or Structural Similarity more info	PubMed
colocalizes_with microtubule	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of protein folding chaperone complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: BAG family molecular chaperone regulator 2

Names: BCL2 associated athanogene 2; bcl-2-associated athanogene 2; dJ417I1.2 (BAG-family molecular chaperone regulator 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004282.4 → NP_004273.1 BAG family molecular chaperone regulator 2

See identical proteins and their annotated locations for NP_004273.1

Status: REVIEWED

Source sequence(s)

AL031321, AL050287, AL136311, CA442969, DA874388

Consensus CDS

CCDS4961.1

UniProtKB/Swiss-Prot

B4DXE2, O95816, Q08AS9, Q6FID0

UniProtKB/TrEMBL

B3KM36, B3KN59

Related

ENSP00000359727.4, ENST00000370693.5

Conserved Domains (1) summary

smart00264
Location:109 → 189

BAG; BAG domains, present in regulator of Hsp70 proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

57172326..57189833

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005249490.5 → XP_005249547.1 BAG family molecular chaperone regulator 2 isoform X1

See identical proteins and their annotated locations for XP_005249547.1

UniProtKB/TrEMBL

B3KM36, B3KN59

Conserved Domains (1) summary

smart00264
Location:76 → 156

BAG; BAG domains, present in regulator of Hsp70 proteins
XM_011514999.4 → XP_011513301.1 BAG family molecular chaperone regulator 2 isoform X1

See identical proteins and their annotated locations for XP_011513301.1

UniProtKB/TrEMBL

B3KM36, B3KN59

Conserved Domains (1) summary

smart00264
Location:76 → 156

BAG; BAG domains, present in regulator of Hsp70 proteins

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

57011351..57028858

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054356854.1 → XP_054212829.1 BAG family molecular chaperone regulator 2 isoform X1
XM_054356855.1 → XP_054212830.1 BAG family molecular chaperone regulator 2 isoform X1