ZNF98 zinc finger protein 98 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF98provided by HGNC
Official Full Name: zinc finger protein 98provided by HGNC
Primary source: HGNC:HGNC:13174
See related: Ensembl:ENSG00000197360 MIM:603980; AllianceGenome:HGNC:13174
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: F7175; ZNF739
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis (RPKM 2.3), kidney (RPKM 0.7) and 13 other tissues See more
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Genomic context

Location:: 19p12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (22391019..22422346, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (22529651..22560967, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (22573821..22605148, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association scan of dental caries in the permanent dentition. EBI GWAS Catalog EBI GWAS CatalogPubMed
GWAS of dental caries patterns in the permanent dentition. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

ERV3 (e-PCR)
- UniSTS:42787

NoName (e-PCR)
- UniSTS:480893

SHGC-111956 (e-PCR)
- UniSTS:168837

D19S1024 (e-PCR)
- UniSTS:12978

NoName (e-PCR)
- UniSTS:481985

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 98

Names: zinc finger protein 739; zinc finger protein F7175

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098626.2 → NP_001092096.1 zinc finger protein 98

See identical proteins and their annotated locations for NP_001092096.1

Status: VALIDATED

Source sequence(s)

AC011494, AC011516

Consensus CDS

CCDS46031.1

UniProtKB/Swiss-Prot

A6NK75

Related

ENSP00000350418.4, ENST00000357774.9

Conserved Domains (6) summary

smart00349
Location:13 → 73

KRAB; krueppel associated box

COG5048
Location:179 → 563

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:324 → 344

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:350 → 372

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:13 → 52

KRAB; KRAB box

pfam13465
Location:364 → 389

zf-H2C2_2; Zinc-finger double domain