SOCS3 suppressor of cytokine signaling 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SOCS3provided by HGNC
Official Full Name: suppressor of cytokine signaling 3provided by HGNC
Primary source: HGNC:HGNC:19391
See related: Ensembl:ENSG00000184557 MIM:604176; AllianceGenome:HGNC:19391
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3
Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
Expression: Broad expression in gall bladder (RPKM 130.8), urinary bladder (RPKM 79.6) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q25.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (78356778..78360925, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (79250300..79254447, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (76352859..76357006, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated inflammatory activation via the miR-30b-5p/SOC3 axis in THP-1 cells.
Title: LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated inflammatory activation via the miR-30b-5p/SOC3 axis in THP-1 cells.
DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the effect of socioeconomic status on elevated body mass index in African American adults.
Title: DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the effect of socioeconomic status on elevated body mass index in African American adults.
An in-silico study to determine susceptibility to cancer by evaluating the coding and non-coding non-synonymous single nucleotide variants in the SOCS3 gene.
Title: An in-silico study to determine susceptibility to cancer by evaluating the coding and non-coding non-synonymous single nucleotide variants in the SOCS3 gene.
SOCS1 and SOCS3 as key checkpoint molecules in the immune responses associated to skin inflammation and malignant transformation.
Title: SOCS1 and SOCS3 as key checkpoint molecules in the immune responses associated to skin inflammation and malignant transformation.
E3 ligase SOCS3 regulates NOD2 expression by ubiquitin proteasome system in lung cancer progression.
Title: E3 ligase SOCS3 regulates NOD2 expression by ubiquitin proteasome system in lung cancer progression.
Exploring the clinical and cellular mechanisms of LncRNA-KCNQ1OT1/miR-29a-3p/SOCS3 molecular axis in cases of unexplained recurrent spontaneous abortion.
Title: Exploring the clinical and cellular mechanisms of LncRNA-KCNQ1OT1/miR-29a-3p/SOCS3 molecular axis in cases of unexplained recurrent spontaneous abortion.
Suppressor of cytokine signaling-3 expression and its regulation in relation to inflammation in Chronic Obstructive Pulmonary Disease.
Title: Suppressor of cytokine signaling-3 expression and its regulation in relation to inflammation in Chronic Obstructive Pulmonary Disease.
SOCS3, Transcriptionally Activated by NR4A1, Induces Apoptosis and Extracellular Matrix Degradation of Vaginal Fibroblasts in Pelvic Organ Prolapse.
Title: SOCS3, Transcriptionally Activated by NR4A1, Induces Apoptosis and Extracellular Matrix Degradation of Vaginal Fibroblasts in Pelvic Organ Prolapse.
DNMTs-mediated SOCS3 methylation promotes the occurrence and development of AML.
Title: DNMTs-mediated SOCS3 methylation promotes the occurrence and development of AML.
Suppressor of Cytokine Signaling-3 Gene Polymorphisms and the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients in Egypt.
Title: Suppressor of Cytokine Signaling-3 Gene Polymorphisms and the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients in Egypt.

Submit: New GeneRIF Correction See all GeneRIFs (455)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-infected clinical samples upregulate SOCS3 expression in ex vivo cultures of monocyte derived dendritic cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 recruits SOCS-3 through IL-10 activation for suppressing IL-6 and IL-6 dependent STAT3 in immature dentritic cells	PubMed
Tat	tat	Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of suppressor of cytokine signaling 3 (SOCS3)	PubMed
	tat	HIV-1 Tat upregulates the expression of suppressor of cytokine signaling 3 (SOCS3) in human primary T cells	PubMed
	tat	HIV-1 Tat 47-59 peptide downregulates gene expression of suppressor of cytokine signaling 3 (SOCS3) in U-937 macrophages	PubMed
	tat	HIV-1 Tat-induced SOCS3 expression inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages in a NF-kappaB-dependent manner	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC283558P1 (e-PCR)
- UniSTS:272409

PMC298718P3 (e-PCR)
- UniSTS:272458

PMC298718P4 (e-PCR)
- UniSTS:272459

PMC148819P2 (e-PCR)
- UniSTS:271015

D17S784 (e-PCR), detects polymorphism
- UniSTS:45031

RH102936 (e-PCR)
- UniSTS:97270

SOCS3_1736 (e-PCR)
- UniSTS:277757

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables miRNA binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables protein tyrosine kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in T-helper 17 cell lineage commitment	TAS Traceable Author Statement more info	PubMed
involved_in branching involved in labyrinthine layer morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-17	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in placenta blood vessel development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	TAS Traceable Author Statement more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: suppressor of cytokine signaling 3

Names: STAT-induced STAT inhibitor 3; cytokine-inducible SH2 protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016851.1 RefSeqGene

Range

4999..8301

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_619

mRNA and Protein(s)

NM_001378932.1 → NP_001365861.1 suppressor of cytokine signaling 3

Status: REVIEWED

Source sequence(s)

AC061992

Consensus CDS

CCDS11756.1

UniProtKB/Swiss-Prot

O14509, O14543

UniProtKB/TrEMBL

Q5U0H7, Q6FI39

Conserved Domains (2) summary

cd10384
Location:35 → 135

SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03737
Location:184 → 225

SOCS_SOCS3; SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the ...
NM_001378933.1 → NP_001365862.1 suppressor of cytokine signaling 3

Status: REVIEWED

Source sequence(s)

AC061992

Consensus CDS

CCDS11756.1

UniProtKB/Swiss-Prot

O14509, O14543

UniProtKB/TrEMBL

Q5U0H7, Q6FI39

Conserved Domains (2) summary

cd10384
Location:35 → 135

SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03737
Location:184 → 225

SOCS_SOCS3; SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the ...
NM_003955.5 → NP_003946.3 suppressor of cytokine signaling 3

See identical proteins and their annotated locations for NP_003946.3

Status: REVIEWED

Source sequence(s)

AC061992

Consensus CDS

CCDS11756.1

UniProtKB/Swiss-Prot

O14509, O14543

UniProtKB/TrEMBL

Q5U0H7, Q6FI39

Related

ENSP00000330341.2, ENST00000330871.3

Conserved Domains (2) summary

cd10384
Location:35 → 135

SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03737
Location:184 → 225

SOCS_SOCS3; SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the ...