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    PARK10 Parkinson disease 10 (susceptibility) [ Homo sapiens (human) ]

    Gene ID: 170534, updated on 31-Aug-2024

    Summary

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    Official Symbol
    PARK10provided by HGNC
    Official Full Name
    Parkinson disease 10 (susceptibility)provided by HGNC
    Primary source
    MIM:606852
    Gene type
    unknown
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AAOPD

    Genomic context

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    Location:
    1p32

    Bibliography

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    Related articles in PubMed

    1. No association of PARK10 polymorphism with Parkinson's disease in Han Chinese population. Tian S, et al. Parkinsonism Relat Disord, 2017 Sep. PMID 28651751
    2. Variation in PARK10 is not associated with risk and age at onset of Parkinson's disease in large clinical cohorts. Simón-Sánchez J, et al. Neurobiol Aging, 2015 Oct. PMID 26260214, Free PMC Article
    3. Fine-mapping and candidate gene investigation within the PARK10 locus. Haugarvoll K, et al. Eur J Hum Genet, 2009 Mar. PMID 18854859, Free PMC Article
    4. A susceptibility gene for late-onset idiopathic Parkinson's disease. Hicks AA, et al. Ann Neurol, 2002 Nov. PMID 12402251
    5. TCEANC2 rs10788972 and rs12046178 variants in the PARK10 region in Chinese Han patients with sporadic Parkinson's disease. Guo Y, et al. Neurobiol Aging, 2015 Dec. PMID 26432391

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
      Title: The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
    2. Our results are consistent with a previous report of no association between rs10788972 and sporadic Parkinson's disease in Han Chinese and a previous report of no influence of PARK10 sequence variants on age at Parkinson's disease onset
      Title: No association of PARK10 polymorphism with Parkinson's disease in Han Chinese population.
    3. Its variant is not related to sporadic PD in Chinese Han population.
      Title: TCEANC2 rs10788972 and rs12046178 variants in the PARK10 region in Chinese Han patients with sporadic Parkinson's disease.
    4. Variation in PARK10 is not associated with risk and age at onset of Parkinson's disease.
      Title: Variation in PARK10 is not associated with risk and age at onset of Parkinson's disease in large clinical cohorts.
    5. PARK10 haplotype is associated with the risk of developing idiopathic PD.
      Title: PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.
    6. Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Bilateral subthalamic stimulation in Parkin and PINK1 parkinsonism.
    7. Genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: High-resolution whole-genome association study of Parkinson disease.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Fine-mapping and candidate gene investigation within the PARK10 locus.
    9. Single nucleotide polymorphisms strongly support HIVEP3 as a candidate for PARK10 in Parkinson disease.
      Title: Investigation of the PARK10 gene in Parkinson disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Associated conditions

    Description Tests
    Parkinson disease 10 (susceptibility)
    OMIM: 606852GeneReviews: Not available

    General gene information

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    Markers

    Other Names

    • Parkinson disease, age at onset of

    Property

    • phenotype only

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