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    DOK3 docking protein 3 [ Homo sapiens (human) ]

    Gene ID: 79930, updated on 14-Nov-2024

    Summary

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    Official Symbol
    DOK3provided by HGNC
    Official Full Name
    docking protein 3provided by HGNC
    Primary source
    HGNC:HGNC:24583
    See related
    Ensembl:ENSG00000146094 MIM:611435; AllianceGenome:HGNC:24583
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DOKL
    Summary
    Predicted to be involved in Ras protein signal transduction; cell surface receptor protein tyrosine kinase signaling pathway; and positive regulation of MAPK cascade. Predicted to be located in ficolin-1-rich granule membrane and plasma membrane. Predicted to be active in cytoplasm. Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bone marrow (RPKM 31.4), spleen (RPKM 15.5) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DOK3 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (177501904..177511100, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (178044890..178054082, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176928905..176938101, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176884168-176884868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176894101-176894646 Neighboring gene drebrin 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:176895193-176895738 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:176895739-176896284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176897377-176897922 Neighboring gene hESC enhancers GRCh37_chr5:176899493-176899996 and GRCh37_chr5:176899997-176900498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176904724-176905224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176911017-176911732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176911733-176912448 Neighboring gene Sharpr-MPRA regulatory region 15492 Neighboring gene PDZ and LIM domain 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176918835-176919378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176919379-176919920 Neighboring gene Sharpr-MPRA regulatory region 583 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176923257-176923998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176925479-176926218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176929555-176930508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176930509-176931460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23727 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176943204-176944028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23728 Neighboring gene DEAD-box helicase 41 Neighboring gene family with sequence similarity 193 member B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176981263-176981766

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression and clinical significance of DOK3 in renal clear cell carcinoma. Wang YF, et al. J Int Med Res, 2023 May. PMID 37235715, Free PMC Article
    2. Porphyromonas gingivalis Activation of Tumor-Associated Macrophages via DOK3 Promotes Recurrence of Oral Squamous Cell Carcinoma. Li CX, et al. Med Sci Monit, 2022 Oct 10. PMID 36210538, Free PMC Article
    3. Elevated expression of DOK3 indicates high suppressive immune cell infiltration and unfavorable prognosis of gliomas. Liu X, et al. Int Immunopharmacol, 2020 Jun. PMID 32193105
    4. Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein. Loh JT, et al. Front Immunol, 2022. PMID 36172386, Free PMC Article
    5. DOK3 negatively regulates LPS responses and endotoxin tolerance. Peng Q, et al. PLoS One, 2012. PMID 22761938, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
      Title: DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
    2. Expression and clinical significance of DOK3 in renal clear cell carcinoma.
      Title: Expression and clinical significance of DOK3 in renal clear cell carcinoma.
    3. Porphyromonas gingivalis Activation of Tumor-Associated Macrophages via DOK3 Promotes Recurrence of Oral Squamous Cell Carcinoma.
      Title: Porphyromonas gingivalis Activation of Tumor-Associated Macrophages via DOK3 Promotes Recurrence of Oral Squamous Cell Carcinoma.
    4. Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein.
      Title: Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein.
    5. Elevated expression of DOK3 indicates high suppressive immune cell infiltration and unfavorable prognosis of gliomas.
      Title: Elevated expression of DOK3 indicates high suppressive immune cell infiltration and unfavorable prognosis of gliomas.
    6. Mutations in DOK3 gene is associated with prostate cancer
      Title: Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.
    7. DOK2 and DOK3 expression was significantly reduced in HTLV-1-infected T cells.
      Title: Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells.
    8. The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters
      Title: The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.
    9. absence of DOK3 increases LPS signaling, contributing to LPS-induced tolerance. Thus, DOK3 plays a role in TLR signaling during both naive and endotoxin-induced tolerant conditions
      Title: DOK3 negatively regulates LPS responses and endotoxin tolerance.
    10. Identification of DOK genes as lung tumor suppressors.
      Title: Identification of DOK genes as lung tumor suppressors.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22570, FLJ39939

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    docking protein 3
    Names
    Dok-like protein
    downstream of tyrosine kinase 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144875.2 → NP_001138347.1  docking protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001138347.1

      Status: VALIDATED

      Source sequence(s)
      AC145098, BC004564, DA931137
      Consensus CDS
      CCDS47350.1
      UniProtKB/Swiss-Prot
      Q7L591
      Related
      ENSP00000325174.6, ENST00000312943.10
      Conserved Domains (2) summary
      cd14676
      Location:9 → 123
      PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
      cl17171
      Location:157 → 215
      PH-like; Pleckstrin homology-like domain

    2. NM_001144876.2 → NP_001138348.1  docking protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC145098, AK097258, BC004564, DA931137
      Consensus CDS
      CCDS47349.1
      UniProtKB/TrEMBL
      A0A6M4C8X9
      Related
      ENSP00000366316.4, ENST00000377112.8
      Conserved Domains (1) summary
      cl17171
      Location:55 → 113
      PH-like; Pleckstrin homology-like domain

    3. NM_001308235.3 → NP_001295164.1  docking protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001295164.1

      Status: VALIDATED

      Source sequence(s)
      AC145098
      Consensus CDS
      CCDS78098.1
      UniProtKB/Swiss-Prot
      E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
      UniProtKB/TrEMBL
      D6RAM3, D6RAV2
      Related
      ENSP00000421688.1, ENST00000501403.6
      Conserved Domains (3) summary
      cd01203
      Location:157 → 255
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cd14676
      Location:9 → 123
      PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
      pfam03154
      Location:259 → 375
      Atrophin-1; Atrophin-1 family

    4. NM_001308236.3 → NP_001295165.1  docking protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001295165.1

      Status: VALIDATED

      Source sequence(s)
      AC145098
      Consensus CDS
      CCDS78098.1
      UniProtKB/Swiss-Prot
      E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
      UniProtKB/TrEMBL
      D6RAM3, D6RAV2
      Related
      ENSP00000424726.2, ENST00000510898.7
      Conserved Domains (3) summary
      cd01203
      Location:157 → 255
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cd14676
      Location:9 → 123
      PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
      pfam03154
      Location:259 → 375
      Atrophin-1; Atrophin-1 family

    5. NM_001375794.1 → NP_001362723.1  docking protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC145098
      Consensus CDS
      CCDS78098.1
      UniProtKB/Swiss-Prot
      E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
      UniProtKB/TrEMBL
      D6RAM3, D6RAV2
      Conserved Domains (3) summary
      cd01203
      Location:157 → 255
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cd14676
      Location:9 → 123
      PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
      pfam03154
      Location:259 → 375
      Atrophin-1; Atrophin-1 family

    6. NM_001375795.1 → NP_001362724.1  docking protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC145098
      Consensus CDS
      CCDS78098.1
      UniProtKB/Swiss-Prot
      E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
      UniProtKB/TrEMBL
      D6RAM3, D6RAV2
      Conserved Domains (3) summary
      cd01203
      Location:157 → 255
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cd14676
      Location:9 → 123
      PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
      pfam03154
      Location:259 → 375
      Atrophin-1; Atrophin-1 family

    7. NM_001375796.1 → NP_001362725.1  docking protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC145098
      Consensus CDS
      CCDS78098.1
      UniProtKB/Swiss-Prot
      E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
      UniProtKB/TrEMBL
      D6RAM3, D6RAV2
      Conserved Domains (3) summary
      cd01203
      Location:157 → 255
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cd14676
      Location:9 → 123
      PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
      pfam03154
      Location:259 → 375
      Atrophin-1; Atrophin-1 family

    8. NM_001375797.2 → NP_001362726.1  docking protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC145098
      Consensus CDS
      CCDS78098.1
      UniProtKB/Swiss-Prot
      E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
      UniProtKB/TrEMBL
      D6RAM3, D6RAV2
      Conserved Domains (3) summary
      cd01203
      Location:157 → 255
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cd14676
      Location:9 → 123
      PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
      pfam03154
      Location:259 → 375
      Atrophin-1; Atrophin-1 family

    9. NM_001375798.1 → NP_001362727.1  docking protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC145098
      Consensus CDS
      CCDS47350.1
      Conserved Domains (2) summary
      cd14676
      Location:9 → 123
      PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
      cl17171
      Location:157 → 215
      PH-like; Pleckstrin homology-like domain

    10. NM_001375799.2 → NP_001362728.1  docking protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC145098
      Consensus CDS
      CCDS47350.1
      Conserved Domains (2) summary
      cd14676
      Location:9 → 123
      PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
      cl17171
      Location:157 → 215
      PH-like; Pleckstrin homology-like domain

    11. NM_001384137.1 → NP_001371066.1  docking protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC145098
      Consensus CDS
      CCDS78098.1
      UniProtKB/Swiss-Prot
      E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
      UniProtKB/TrEMBL
      D6RAM3, D6RAV2
      Conserved Domains (3) summary
      cd01203
      Location:157 → 255
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cd14676
      Location:9 → 123
      PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
      pfam03154
      Location:259 → 375
      Atrophin-1; Atrophin-1 family

    12. NM_001384138.1 → NP_001371067.1  docking protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC145098
      UniProtKB/Swiss-Prot
      E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
      Conserved Domains (3) summary
      cd01203
      Location:156 → 254
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cd14676
      Location:9 → 122
      PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
      pfam03154
      Location:258 → 374
      Atrophin-1; Atrophin-1 family

    13. NM_001384139.1 → NP_001371068.1  docking protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC145098
      UniProtKB/Swiss-Prot
      E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
      Conserved Domains (3) summary
      cd01203
      Location:156 → 254
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cd14676
      Location:9 → 122
      PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
      pfam03154
      Location:258 → 374
      Atrophin-1; Atrophin-1 family

    14. NM_024872.4 → NP_079148.3  docking protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC145098
      Consensus CDS
      CCDS78098.1
      UniProtKB/Swiss-Prot
      E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
      UniProtKB/TrEMBL
      D6RAM3, D6RAV2
      Related
      ENSP00000349727.5, ENST00000357198.9
      Conserved Domains (3) summary
      cd01203
      Location:157 → 255
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cd14676
      Location:9 → 123
      PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
      pfam03154
      Location:259 → 375
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      177501904..177511100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417774.1 → XP_047273730.1  docking protein 3 isoform X2

    2. XM_047417775.1 → XP_047273731.1  docking protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A6M4C8X9

    3. XM_047417771.1 → XP_047273727.1  docking protein 3 isoform X1

    4. XM_047417772.1 → XP_047273728.1  docking protein 3 isoform X2

    5. XM_047417773.1 → XP_047273729.1  docking protein 3 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      178044890..178054082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353547.1 → XP_054209522.1  docking protein 3 isoform X4

      UniProtKB/TrEMBL
      D6RAM3, D6RAV2

    2. XM_054353551.1 → XP_054209526.1  docking protein 3 isoform X2

    3. XM_054353552.1 → XP_054209527.1  docking protein 3 isoform X3

    4. XM_054353548.1 → XP_054209523.1  docking protein 3 isoform X1

    5. XM_054353549.1 → XP_054209524.1  docking protein 3 isoform X2

    6. XM_054353550.1 → XP_054209525.1  docking protein 3 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7L591.2 GenPept UniProtKB/Swiss-Prot:Q7L591

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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