TUT7 terminal uridylyl transferase 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TUT7provided by HGNC
Official Full Name: terminal uridylyl transferase 7provided by HGNC
Primary source: HGNC:HGNC:25817
See related: Ensembl:ENSG00000083223 MIM:613467; AllianceGenome:HGNC:25817
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PAPD6; TENT3B; ZCCHC6
Summary: Enables RNA uridylyltransferase activity and miRNA binding activity. Involved in RNA metabolic process and retrotransposon silencing by mRNA destabilization. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in prostate (RPKM 7.8), skin (RPKM 6.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q21.33

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (86287733..86354410, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (98438962..98505744, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (88902648..88969325, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis.
Title: Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis.
TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
Title: TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type.
Title: RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type.
High ZCCHC6 expression is associated with head and neck squamous cell carcinoma.
Title: Induction of ZCCHC6 expression in peripheral blood mononuclear cells by HNSCC secretions.
ZCCHC6 (TUT7) was markedly up-regulated in damaged cartilage from human osteoarthritis (OA) patients and from wild-type mice with surgically induced OA.
Title: Genetic Inactivation of ZCCHC6 Suppresses Interleukin-6 Expression and Reduces the Severity of Experimental Osteoarthritis in Mice.
This tail-U-mediated repression (TUMR) is abolished in cells lacking the uridylation enzymes TUT4 and TUT7, indicating that uridylation alters miRNA function by modulating target recognition. We identified a set of non-canonical targets in human cells that are specifically regulated by uridylated miR-27a.
Title: 3' Uridylation Confers miRNAs with Non-canonical Target Repertoires.
Uridine residues added by TUT7 in the cytoplasm inhibit initiation of reverse transcription of LINE-1 mRNAs once they are reimported to the nucleus.
Title: Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s.
Results from a study on gene expression variability markers in early-stage human embryos shows that TUT7 (ZCCHC6) is a putative expression variability marker for the 3-day, 8-cell embryo stage.
Title: Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
Following an intratracheal challenge with S. pneumoniae, Zcchc6 deficiency led to a modest but significant increase in the expression of select cytokines including IL-6, CXCL1, and CXCL5. These findings were recapitulated in vitro whereby Zcchc6-deficient macrophages exhibited similar increases in cytokine expression due to bacterial stimulation
Title: The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.
The authors found that TUT4(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU).
Title: Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A009W34 (e-PCR)
- UniSTS:58880

RH102753 (e-PCR)
- UniSTS:97087

STS-F09563 (e-PCR)
- UniSTS:71751

RH41959 (e-PCR)
- UniSTS:57448

STS-D20387 (e-PCR)
- UniSTS:18084

RH118983 (e-PCR)
- UniSTS:138951

G32922 (e-PCR)
- UniSTS:117500

Clone Names

DKFZp666B142, DKFZp686F119, DKFZp686I1269, DKFZp686C11112

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA uridylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA uridylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables uridylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA 3' uridylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA 3' uridylation	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA 3' uridylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA 3'-end processing	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in histone mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in oocyte maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in polyuridylation-dependent mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in pre-miRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in retrotransposon silencing by mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: terminal uridylyltransferase 7

Names: PAP associated domain containing 6; TUTase 7; zinc finger CCHC domain-containing protein 6; zinc finger CCHC-type containing 6; zinc finger, CCHC domain containing 6

NP_001171988.1

EC 2.7.7.52

NP_001172003.1

EC 2.7.7.52

NP_001317647.1

EC 2.7.7.52

NP_078893.2

EC 2.7.7.52

XP_005252264.1

EC 2.7.7.52

XP_005252265.1

EC 2.7.7.52

XP_006717346.1

EC 2.7.7.52

XP_011517313.1

EC 2.7.7.52

XP_011517314.1

EC 2.7.7.52

XP_011517315.1

EC 2.7.7.52

XP_011517316.1

EC 2.7.7.52

XP_011517317.1

EC 2.7.7.52

XP_011517318.1

EC 2.7.7.52

XP_016870619.1

EC 2.7.7.52

XP_016870620.1

EC 2.7.7.52

XP_047279823.1

EC 2.7.7.52

XP_047279824.1

EC 2.7.7.52

XP_047279825.1

EC 2.7.7.52

XP_047279826.1

EC 2.7.7.52

XP_054219767.1

EC 2.7.7.52

XP_054219768.1

EC 2.7.7.52

XP_054219769.1

EC 2.7.7.52

XP_054219770.1

EC 2.7.7.52

XP_054219771.1

EC 2.7.7.52

XP_054219772.1

EC 2.7.7.52

XP_054219773.1

EC 2.7.7.52

XP_054219774.1

EC 2.7.7.52

XP_054219775.1

EC 2.7.7.52

XP_054219776.1

EC 2.7.7.52

XP_054219777.1

EC 2.7.7.52

XP_054219778.1

EC 2.7.7.52

XP_054219779.1

EC 2.7.7.52

XP_054219780.1

EC 2.7.7.52

XP_054219781.1

EC 2.7.7.52

XP_054219782.1

EC 2.7.7.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001185059.2 → NP_001171988.1 terminal uridylyltransferase 7 isoform 1

See identical proteins and their annotated locations for NP_001171988.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein isoform.

Source sequence(s)

AK055546, AK055948, BC015897, CR933643

Consensus CDS

CCDS35057.1

UniProtKB/Swiss-Prot

Q5H9T0, Q5VYS5, Q5VYS7, Q5VYS8, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6

Conserved Domains (4) summary

cd05402
Location:1021 → 1138

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00343
Location:1452 → 1468

ZnF_C2HC; zinc finger

pfam03828
Location:1233 → 1286

PAP_assoc; Cid1 family poly A polymerase

pfam16631
Location:1371 → 1450

TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
NM_001185074.2 → NP_001172003.1 terminal uridylyltransferase 7 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two different regions of sequence, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

AK055546, AL832026, BC015897, BU734789, CA773862

Consensus CDS

CCDS55323.1

Related

ENSP00000365127.2, ENST00000375960.6

Conserved Domains (5) summary

cd05402
Location:830 → 902

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00343
Location:1216 → 1232

ZnF_C2HC; zinc finger

pfam03828
Location:997 → 1050

PAP_assoc; Cid1 family poly A polymerase

pfam16631
Location:1135 → 1214

TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

cl11966
Location:315 → 360

NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
NM_001330718.2 → NP_001317647.1 terminal uridylyltransferase 7 isoform 3

Status: VALIDATED

Source sequence(s)

AK055948, AL137849, AL353678, CN419677, CR933643, CR933644, DB156789

Consensus CDS

CCDS83383.1

UniProtKB/TrEMBL

X6R3Q3

Related

ENSP00000277141.6, ENST00000277141.10
NM_024617.4 → NP_078893.2 terminal uridylyltransferase 7 isoform 1

See identical proteins and their annotated locations for NP_078893.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein isoform.

Source sequence(s)

AK055546, BC015897, BC016387, BU734789, CA773862, DC377509

Consensus CDS

CCDS35057.1

UniProtKB/Swiss-Prot

Q5H9T0, Q5VYS5, Q5VYS7, Q5VYS8, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6

Related

ENSP00000365130.3, ENST00000375963.8

Conserved Domains (4) summary

cd05402
Location:1021 → 1138

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00343
Location:1452 → 1468

ZnF_C2HC; zinc finger

pfam03828
Location:1233 → 1286

PAP_assoc; Cid1 family poly A polymerase

pfam16631
Location:1371 → 1450

TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

86287733..86354410 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005252207.4 → XP_005252264.1 terminal uridylyltransferase 7 isoform X6

See identical proteins and their annotated locations for XP_005252264.1

Conserved Domains (3) summary

cd05402
Location:315 → 427

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00343
Location:1452 → 1468

ZnF_C2HC; zinc finger

COG5260
Location:979 → 1310

TRF4; DNA polymerase sigma [Replication, recombination and repair]
XM_006717283.2 → XP_006717346.1 terminal uridylyltransferase 7 isoform X2

Conserved Domains (4) summary

cd05402
Location:1021 → 1138

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00343
Location:1452 → 1468

ZnF_C2HC; zinc finger

pfam03828
Location:1233 → 1286

PAP_assoc; Cid1 family poly A polymerase

pfam16631
Location:1371 → 1450

TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
XM_017015131.2 → XP_016870620.1 terminal uridylyltransferase 7 isoform X4

UniProtKB/Swiss-Prot

Q5H9T0, Q5VYS5, Q5VYS7, Q5VYS8, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6

Conserved Domains (4) summary

cd05402
Location:1021 → 1138

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00343
Location:1452 → 1468

ZnF_C2HC; zinc finger

pfam03828
Location:1233 → 1286

PAP_assoc; Cid1 family poly A polymerase

pfam16631
Location:1371 → 1450

TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
XM_017015130.2 → XP_016870619.1 terminal uridylyltransferase 7 isoform X4

UniProtKB/Swiss-Prot

Q5H9T0, Q5VYS5, Q5VYS7, Q5VYS8, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6

Conserved Domains (4) summary

cd05402
Location:1021 → 1138

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00343
Location:1452 → 1468

ZnF_C2HC; zinc finger

pfam03828
Location:1233 → 1286

PAP_assoc; Cid1 family poly A polymerase

pfam16631
Location:1371 → 1450

TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
XM_047423867.1 → XP_047279823.1 terminal uridylyltransferase 7 isoform X2
XM_011519012.3 → XP_011517314.1 terminal uridylyltransferase 7 isoform X1

See identical proteins and their annotated locations for XP_011517314.1

Conserved Domains (4) summary

cd05402
Location:1021 → 1138

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00343
Location:1452 → 1468

ZnF_C2HC; zinc finger

pfam03828
Location:1233 → 1286

PAP_assoc; Cid1 family poly A polymerase

pfam16631
Location:1371 → 1450

TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
XM_011519016.2 → XP_011517318.1 terminal uridylyltransferase 7 isoform X5

Conserved Domains (4) summary

cd05402
Location:1021 → 1138

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00343
Location:1452 → 1468

ZnF_C2HC; zinc finger

pfam03828
Location:1233 → 1286

PAP_assoc; Cid1 family poly A polymerase

pfam16631
Location:1371 → 1450

TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
XM_047423869.1 → XP_047279825.1 terminal uridylyltransferase 7 isoform X6
XM_047423868.1 → XP_047279824.1 terminal uridylyltransferase 7 isoform X6
XM_011519015.2 → XP_011517317.1 terminal uridylyltransferase 7 isoform X3

Conserved Domains (4) summary

cd05402
Location:1021 → 1138

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00343
Location:1452 → 1468

ZnF_C2HC; zinc finger

pfam03828
Location:1233 → 1286

PAP_assoc; Cid1 family poly A polymerase

pfam16631
Location:1371 → 1450

TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
XM_011519011.3 → XP_011517313.1 terminal uridylyltransferase 7 isoform X1

See identical proteins and their annotated locations for XP_011517313.1

Conserved Domains (4) summary

cd05402
Location:1021 → 1138

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00343
Location:1452 → 1468

ZnF_C2HC; zinc finger

pfam03828
Location:1233 → 1286

PAP_assoc; Cid1 family poly A polymerase

pfam16631
Location:1371 → 1450

TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
XM_011519014.3 → XP_011517316.1 terminal uridylyltransferase 7 isoform X1

See identical proteins and their annotated locations for XP_011517316.1

Conserved Domains (4) summary

cd05402
Location:1021 → 1138

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00343
Location:1452 → 1468

ZnF_C2HC; zinc finger

pfam03828
Location:1233 → 1286

PAP_assoc; Cid1 family poly A polymerase

pfam16631
Location:1371 → 1450

TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
XM_011519013.3 → XP_011517315.1 terminal uridylyltransferase 7 isoform X1

See identical proteins and their annotated locations for XP_011517315.1

Conserved Domains (4) summary

cd05402
Location:1021 → 1138

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00343
Location:1452 → 1468

ZnF_C2HC; zinc finger

pfam03828
Location:1233 → 1286

PAP_assoc; Cid1 family poly A polymerase

pfam16631
Location:1371 → 1450

TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
XM_005252208.3 → XP_005252265.1 terminal uridylyltransferase 7 isoform X7

Conserved Domains (2) summary

cd05402
Location:1021 → 1138

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

pfam03828
Location:1233 → 1286

PAP_assoc; Cid1 family poly A polymerase
XM_047423870.1 → XP_047279826.1 terminal uridylyltransferase 7 isoform X8