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    CMTR1 cap methyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 23070, updated on 3-Nov-2024

    Summary

    Official Symbol
    CMTR1provided by HGNC
    Official Full Name
    cap methyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:21077
    See related
    Ensembl:ENSG00000137200 MIM:616189; AllianceGenome:HGNC:21077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MTr1; hMTr1; FTSJD2; KIAA0082
    Summary
    Enables mRNA (nucleoside-2'-O-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 31.1), spleen (RPKM 12.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CMTR1 in Genome Data Viewer
    Location:
    6p21.2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (37423985..37481508)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (37247428..37305049)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (37400997..37449284)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24457 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:37335886-37337085 Neighboring gene RNA, 7SL, cytoplasmic 273, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7630 Neighboring gene ring finger protein 8 Neighboring gene uncharacterized LOC107986531 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:37400679-37401180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17140 Neighboring gene MPRA-validated peak5792 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:37427605-37428259 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:37448259-37448959 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:37456899-37457744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24459 Neighboring gene coiled-coil domain containing 167 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37480625-37481226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37481227-37481828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37483099-37483883 Neighboring gene long intergenic non-protein coding RNA 2520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37483884-37484668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24462 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:37487335-37487506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24463

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ22156, KIAA0082

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in 7-methylguanosine mRNA capping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in 7-methylguanosine mRNA capping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Names
    FtsJ methyltransferase domain containing 2
    ISG95
    S-adenosyl-L-methionine-dependent methyltransferase FTSJD2
    cap1 2'O-ribose methyltransferase 1
    ftsJ methyltransferase domain-containing protein 2
    interferon-stimulated gene 95 kDa protein
    NP_055865.1
    XP_047274418.1
    XP_047274419.1
    XP_054210779.1
    XP_054210780.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015050.3NP_055865.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

      See identical proteins and their annotated locations for NP_055865.1

      Status: VALIDATED

      Source sequence(s)
      BC010731, BC031890, DA508836
      Consensus CDS
      CCDS4835.1
      UniProtKB/Swiss-Prot
      A8K949, Q14670, Q8N1G2, Q96FJ9
      Related
      ENSP00000362550.4, ENST00000373451.9
      Conserved Domains (3) summary
      pfam01585
      Location:87129
      G-patch; G-patch domain
      pfam01728
      Location:232448
      FtsJ; FtsJ-like methyltransferase
      cl12015
      Location:625716
      Adenylation_DNA_ligase_like; Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      37423985..37481508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418463.1XP_047274419.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K949, Q14670, Q8N1G2, Q96FJ9
    2. XM_047418462.1XP_047274418.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K949, Q14670, Q8N1G2, Q96FJ9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      37247428..37305049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354804.1XP_054210779.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K949, Q14670, Q8N1G2, Q96FJ9
    2. XM_054354805.1XP_054210780.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K949, Q14670, Q8N1G2, Q96FJ9