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    NUP133 nucleoporin 133 [ Homo sapiens (human) ]

    Gene ID: 55746, updated on 3-Nov-2024

    Summary

    Official Symbol
    NUP133provided by HGNC
    Official Full Name
    nucleoporin 133provided by HGNC
    Primary source
    HGNC:HGNC:18016
    See related
    Ensembl:ENSG00000069248 MIM:607613; AllianceGenome:HGNC:18016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAMOS8; NPHS18; hNUP133
    Summary
    The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 11.8), brain (RPKM 11.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NUP133 in Genome Data Viewer
    Location:
    1q42.13
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (229440259..229508341, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (228818956..228887101, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (229576006..229644088, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904541 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:229550455-229550955 Neighboring gene RN7SK pseudogene 276 Neighboring gene NANOG hESC enhancer GRCh37_chr1:229552218-229552719 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:229553351-229554106 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:229554107-229554860 Neighboring gene Sharpr-MPRA regulatory region 11409 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:229566843-229567462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:229567463-229568084 Neighboring gene Sharpr-MPRA regulatory region 2214 Neighboring gene MPRA-validated peak754 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1929 Neighboring gene NANOG hESC enhancer GRCh37_chr1:229576278-229576818 Neighboring gene actin alpha 1, skeletal muscle Neighboring gene Sharpr-MPRA regulatory region 12306 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2702 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2703 Neighboring gene Sharpr-MPRA regulatory region 12340 Neighboring gene NUP133 divergent transcript Neighboring gene ATP binding cassette subfamily B member 10 Neighboring gene RNA, U4 small nuclear 21, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of nucleoporin 133kDa (NUP133) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Mermaid (NUP133) shares glycan specificity with DC-SIGN and inhibits the interaction between DC-SIGN and HIV-1 gp120 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with NUP133 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10814, MGC21133

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nephron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural tube development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear pore organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in paraxial mesoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in somite development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope TAS
    Traceable Author Statement
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of nuclear pore outer ring IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear pore outer ring IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear pore outer ring NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear pore complex protein Nup133
    Names
    133 kDa nucleoporin
    nucleoporin 133kD
    nucleoporin 133kDa
    nucleoporin Nup133

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011969.1 RefSeqGene

      Range
      5001..73083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_018230.3NP_060700.2  nuclear pore complex protein Nup133

      See identical proteins and their annotated locations for NP_060700.2

      Status: REVIEWED

      Source sequence(s)
      AL121990, AL139252, AL160004
      Consensus CDS
      CCDS1579.1
      UniProtKB/Swiss-Prot
      B2RAZ8, Q5T8N0, Q8WUM0, Q9H9W2, Q9NV71, Q9NVC4
      UniProtKB/TrEMBL
      B4E206
      Related
      ENSP00000261396.3, ENST00000261396.6
      Conserved Domains (1) summary
      pfam03177
      Location:5951098
      Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      229440259..229508341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424979.1XP_047280935.1  nuclear pore complex protein Nup133 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      228818956..228887101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337617.1XP_054193592.1  nuclear pore complex protein Nup133 isoform X1