SLC25A10 solute carrier family 25 member 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC25A10provided by HGNC
Official Full Name: solute carrier family 25 member 10provided by HGNC
Primary source: HGNC:HGNC:10980
See related: Ensembl:ENSG00000183048 MIM:606794; AllianceGenome:HGNC:10980
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DIC; MTDPS19
Summary: This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Expression: Broad expression in kidney (RPKM 33.1), liver (RPKM 15.3) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q25.3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (81712284..81721012)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (82629200..82637941)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (79679314..79688042)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of PYCR1 in inhibiting 5-fluorouracil-induced ferroptosis and apoptosis through SLC25A10 in colorectal cancer.
Title: The role of PYCR1 in inhibiting 5-fluorouracil-induced ferroptosis and apoptosis through SLC25A10 in colorectal cancer.
identified a new protein-protein interaction mechanism in which CLOCK can directly regulate cell metabolism via the mitochondrial membrane transporter SLC25A10.
Title: The circadian protein CLOCK regulates cell metabolism via the mitochondrial carrier SLC25A10.
Data show that targeting of mitochondrial dicarboxylate carrier (SLC25A10) was effective in overcoming chronic-cycling hypoxia-induced enhanced death resistance in vitro and in vivo by disturbing increased antioxidant capacity.
Title: Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia.
Study report the first recessive mutations of SLC25A10 associated to an inherited severe mitochondrial neurodegenerative disorder. We propose that SLC25A10 loss-of-function causes pathological disarrangements in respiratory-demanding conditions and oxidative stress vulnerability.
Title: SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency.
study identifies novel genes associated with insulin sensitivity in adipocytes in women independently of obesity. KFL15 and SLC25A10 are inhibitors of insulin-stimulated lipogenesis under conditions when glucose transport is the rate limiting step
Title: Global transcriptome profiling identifies KLF15 and SLC25A10 as modifiers of adipocytes insulin sensitivity in obese women.
the SLC25A10 carrier plays an important role in regulating redox homeostasis to protect confluent cells against oxidative stress.
Title: The mitochondrial carrier SLC25A10 regulates cancer cell growth.
Compares and contrasts all the known human SLC25A* genes and includes functional information.
Title: The mitochondrial transporter family SLC25: identification, properties and physiopathology.
SLC25A10 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Title: The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Slc25a10 plays an important role in supplying malate for citrate transport required for fatty acid synthesis and its inhibition might effectively reduce lipid accumulation in adipose tissues
Title: Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Mitochondrial DNA depletion syndrome 19 MedGen: C5436514 OMIM: 618972 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Genome-wide association scan of dental caries in the permanent dentition. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables dicarboxylic acid transmembrane transporter activity	EXP Inferred from Experiment more info	PubMed
enables dicarboxylic acid transmembrane transporter activity	TAS Traceable Author Statement more info
enables malate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxaloacetate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables succinate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiosulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in dicarboxylic acid transport	TAS Traceable Author Statement more info
involved_in gluconeogenesis	TAS Traceable Author Statement more info
involved_in glyceraldehyde-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in malate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transport	TAS Traceable Author Statement more info
involved_in oxaloacetate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxaloacetate(2-) transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in succinate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sulfate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfide oxidation, using sulfide:quinone oxidoreductase	TAS Traceable Author Statement more info
involved_in thiosulfate transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info
located_in mitochondrion	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: mitochondrial dicarboxylate carrier

Names: dicarboxylate ion carrier; solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270888.2 → NP_001257817.1 mitochondrial dicarboxylate carrier isoform 1

See identical proteins and their annotated locations for NP_001257817.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.

Source sequence(s)

AC139530, AI081980, BC015797, HY259124

Consensus CDS

CCDS59301.1

UniProtKB/TrEMBL

A0A0S2Z3G3

Related

ENSP00000328403.5, ENST00000331531.9

Conserved Domains (1) summary

pfam00153
Location:95 → 190

Mito_carr; Mitochondrial carrier protein
NM_001270953.2 → NP_001257882.1 mitochondrial dicarboxylate carrier isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is longer than isoform 1.

Source sequence(s)

AC139530, AI081980, BC007355, BM561945, HY259124

Consensus CDS

CCDS74176.1

UniProtKB/TrEMBL

F6RGN5

Related

ENSP00000446242.2, ENST00000545862.5

Conserved Domains (1) summary

pfam00153
Location:13 → 93

Mito_carr; Mitochondrial carrier protein
NM_012140.5 → NP_036272.2 mitochondrial dicarboxylate carrier isoform 2

See identical proteins and their annotated locations for NP_036272.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC139530, AI081980, BC007355, HY259124

Consensus CDS

CCDS11786.1

UniProtKB/Swiss-Prot

Q542Z3, Q96BA1, Q96IP1, Q9UBX3

UniProtKB/TrEMBL

A0A0S2Z382

Related

ENSP00000345580.5, ENST00000350690.10

Conserved Domains (1) summary

pfam00153
Location:198 → 284

Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

81712284..81721012

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047435431.1 → XP_047291387.1 mitochondrial dicarboxylate carrier isoform X1
XM_047435432.1 → XP_047291388.1 mitochondrial dicarboxylate carrier isoform X2

UniProtKB/TrEMBL

B4E1E9

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

82629200..82637941

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054315161.1 → XP_054171136.1 mitochondrial dicarboxylate carrier isoform X1
XM_054315162.1 → XP_054171137.1 mitochondrial dicarboxylate carrier isoform X2

UniProtKB/TrEMBL

B4E1E9