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    MPDZ multiple PDZ domain crumbs cell polarity complex component [ Homo sapiens (human) ]

    Gene ID: 8777, updated on 3-Apr-2024

    Summary

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    Official Symbol
    MPDZprovided by HGNC
    Official Full Name
    multiple PDZ domain crumbs cell polarity complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:7208
    See related
    Ensembl:ENSG00000107186 MIM:603785; AllianceGenome:HGNC:7208
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HYC2; MUPP1
    Summary
    The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in liver (RPKM 12.7), fat (RPKM 10.5) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    9p23
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (13105707..13279692, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (13115022..13289091, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (13105706..13279691, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 137 Neighboring gene peroxiredoxin 1 pseudogene 1 Neighboring gene lupus La protein-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:13037568-13038084 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:13251447-13252059 Neighboring gene Sharpr-MPRA regulatory region 14432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:13277167-13277882 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:13277883-13278598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:13278599-13279314 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:13369413-13369918 Neighboring gene long intergenic non-protein coding RNA 1235 Neighboring gene uncharacterized LOC105375977

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Evaluating the Association between Keratoconus and Reported Genetic Loci in a Han Chinese Population. Hao XD, et al. Ophthalmic Genet, 2015 Jun. PMID 25675348
    2. The multi-PDZ domain protein-1 (MUPP-1) expression regulates cellular levels of the PALS-1/PATJ polarity complex. Assémat E, et al. Exp Cell Res, 2013 Oct 15. PMID 23880463
    3. Mutation in MPDZ causes severe congenital hydrocephalus. Al-Dosari MS, et al. J Med Genet, 2013 Jan. PMID 23240096
    4. Genetic variability in the NMDA-dependent AMPA trafficking cascade is associated with alcohol dependence. Karpyak VM, et al. Addict Biol, 2012 Jul. PMID 21762291, Free PMC Article
    5. Evaluating the association between MPDZ-NF1B rs1324183 and keratoconus in an independent northwestern Chinese population. Yuan S, et al. BMC Ophthalmol, 2022 Mar 19. PMID 35305607, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MPDZ is associated with immune infiltration and regulates migration and invasion by switching YAP1 phosphorylation in colorectal cancer.
      Title: MPDZ is associated with immune infiltration and regulates migration and invasion by switching YAP1 phosphorylation in colorectal cancer.
    2. Retinal manifestations in autosomal recessive MPDZ maculopathy: report of two cases and literature review.
      Title: Retinal manifestations in autosomal recessive MPDZ maculopathy: report of two cases and literature review.
    3. Evaluating the association between MPDZ-NF1B rs1324183 and keratoconus in an independent northwestern Chinese population.
      Title: Evaluating the association between MPDZ-NF1B rs1324183 and keratoconus in an independent northwestern Chinese population.
    4. ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for autosomal recessive nonsyndromic hearing impairment.
      Title: ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for autosomal recessive nonsyndromic hearing impairment.
    5. MPDZ as a novel epigenetic silenced tumor suppressor inhibits growth and progression of lung cancer through the Hippo-YAP pathway.
      Title: MPDZ as a novel epigenetic silenced tumor suppressor inhibits growth and progression of lung cancer through the Hippo-YAP pathway.
    6. Observation of nine previously reported and 10 non-reported SLC4A11 mutations among 20 Iranian CHED probands and identification of an MPDZ mutation as possible cause of CHED and FECD in one family.
      Title: Observation of nine previously reported and 10 non-reported SLC4A11 mutations among 20 Iranian CHED probands and identification of an MPDZ mutation as possible cause of CHED and FECD in one family.
    7. DAPLE and MPDZ function as cooperative partners at apical junctions.
      Title: DAPLE and MPDZ bind to each other and cooperate to promote apical cell constriction.
    8. Tumor angiogenesis was enhanced upon endothelial-specific inactivation of MPDZ leading to an excessively branched and poorly functional vessel network resulting in tumor hypoxia through DLL4-induced Notch signaling.
      Title: MPDZ promotes DLL4-induced Notch signaling during angiogenesis.
    9. This study confirmed the association of SNP rs1324183 in MPDZ-NF1B with keratoconus and revealed the association of this SNP with keratoconus severity and corneal parameters. It is thus a putative genetic marker for monitoring the progression of keratoconus to a severe form and facilitating early intervention.
      Title: Analysis of multiple genetic loci reveals MPDZ-NF1B rs1324183 as a putative genetic marker for keratoconus.
    10. two peptides (SIAPNV(-COOH) and SIVMNV(-COOH)) were identified to have considerably improved affinity with K d increase by ~tenfold relative to wild type peptide. Thus, the two peptides are considered as promising lead entities to develop therapeutic molecular agents with high efficacy and specificity to target CaMKIIalpha-MUPP1 interaction.
      Title: Structure-based identification of CaMKIIα-interacting MUPP1 PDZ domains and rational design of peptide ligands to target such interaction in human fertilization.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Hydrocephalus, nonsyndromic, autosomal recessive 2
    MedGen: C3554691 OMIM: 615219 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of multiple PDZ domain protein (MPDZ) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25909, FLJ34626, FLJ90240, DKFZp781P216

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical part of cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    multiple PDZ domain protein
    Names
    multi-PDZ domain protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042810.2 RefSeqGene

      Range
      5000..178985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001261406.2 → NP_001248335.1  multiple PDZ domain protein isoform 2

      See identical proteins and their annotated locations for NP_001248335.1

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS59120.1
      UniProtKB/TrEMBL
      F5H1U9
      Related
      ENSP00000415208.1, ENST00000447879.6
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1149 → 1240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1529 → 1593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    2. NM_001261407.2 → NP_001248336.1  multiple PDZ domain protein isoform 3

      See identical proteins and their annotated locations for NP_001248336.1

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS59119.1
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1149 → 1240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1529 → 1593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    3. NM_001330637.2 → NP_001317566.1  multiple PDZ domain protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS83342.1
      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1149 → 1240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2; L27_2
      pfam16667
      Location:1562 → 1626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    4. NM_001375413.1 → NP_001362342.1  multiple PDZ domain protein isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1149 → 1240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1595 → 1659
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    5. NM_001375416.1 → NP_001362345.1  multiple PDZ domain protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS59120.1
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1149 → 1240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1529 → 1593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    6. NM_001375417.1 → NP_001362346.1  multiple PDZ domain protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS59120.1
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1149 → 1240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1529 → 1593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    7. NM_001375418.1 → NP_001362347.1  multiple PDZ domain protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS59120.1
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1149 → 1240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1529 → 1593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    8. NM_001375419.1 → NP_001362348.1  multiple PDZ domain protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS59119.1
      UniProtKB/TrEMBL
      F5H1U9
      Related
      ENSP00000444151.1, ENST00000536827.5
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1149 → 1240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1529 → 1593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    9. NM_001375420.1 → NP_001362349.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1916 → 1999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1492 → 1556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    10. NM_001375421.1 → NP_001362350.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1916 → 1999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1492 → 1556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    11. NM_001375422.1 → NP_001362351.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1916 → 1999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1492 → 1556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    12. NM_001375423.1 → NP_001362352.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1916 → 1999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1492 → 1556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    13. NM_001375424.1 → NP_001362353.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1916 → 1999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1492 → 1556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    14. NM_001375425.1 → NP_001362354.1  multiple PDZ domain protein isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1887 → 1970
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1492 → 1556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    15. NM_001375426.1 → NP_001362355.1  multiple PDZ domain protein isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1887 → 1970
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1492 → 1556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    16. NM_001375427.1 → NP_001362356.1  multiple PDZ domain protein isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1850 → 1933
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1426 → 1490
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    17. NM_001378778.1 → NP_001365707.1  multiple PDZ domain protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS83342.1
      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
      Related
      ENSP00000320006.7, ENST00000319217.12

    18. NM_003829.5 → NP_003820.2  multiple PDZ domain protein isoform 1

      See identical proteins and their annotated locations for NP_003820.2

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS47951.1
      UniProtKB/TrEMBL
      F5H1U9
      Related
      ENSP00000439807.1, ENST00000541718.5
      Conserved Domains (4) summary
      pfam09045
      Location:6 → 63
      L27_2; L27_2
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1149 → 1240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16667
      Location:1562 → 1626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      13105707..13279692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424033.1 → XP_047279989.1  multiple PDZ domain protein isoform X5

    2. XM_017015252.2 → XP_016870741.1  multiple PDZ domain protein isoform X2

      UniProtKB/TrEMBL
      F5H1U9

    3. XM_006716888.4 → XP_006716951.1  multiple PDZ domain protein isoform X3

      See identical proteins and their annotated locations for XP_006716951.1

      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      pfam09045
      Location:6 → 63
      L27_2; L27_2
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1149 → 1240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16667
      Location:1562 → 1626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    4. XM_047424044.1 → XP_047280000.1  multiple PDZ domain protein isoform X8

    5. XM_047424016.1 → XP_047279972.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    6. XM_047424035.1 → XP_047279991.1  multiple PDZ domain protein isoform X6

    7. XM_006716886.4 → XP_006716949.1  multiple PDZ domain protein isoform X1

      See identical proteins and their annotated locations for XP_006716949.1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1149 → 1240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2; L27_2
      pfam16667
      Location:1562 → 1626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    8. XM_047424042.1 → XP_047279998.1  multiple PDZ domain protein isoform X8

    9. XM_047424025.1 → XP_047279981.1  multiple PDZ domain protein isoform X4

    10. XM_024447708.2 → XP_024303476.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1149 → 1240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2; L27_2
      pfam16667
      Location:1562 → 1626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    11. XM_047424039.1 → XP_047279995.1  multiple PDZ domain protein isoform X8

    12. XM_047424028.1 → XP_047279984.1  multiple PDZ domain protein isoform X4

    13. XM_047424013.1 → XP_047279969.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    14. XM_047424045.1 → XP_047280001.1  multiple PDZ domain protein isoform X8

    15. XM_047424015.1 → XP_047279971.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    16. XM_047424043.1 → XP_047279999.1  multiple PDZ domain protein isoform X8

    17. XM_047424031.1 → XP_047279987.1  multiple PDZ domain protein isoform X4

    18. XM_047424046.1 → XP_047280002.1  multiple PDZ domain protein isoform X9

      Conserved Domains (4) summary
      smart00228
      Location:374 → 463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:1149 → 1240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:6 → 63
      L27_2
      pfam16667
      Location:1595 → 1659
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    19. XM_047424037.1 → XP_047279993.1  multiple PDZ domain protein isoform X8

    20. XM_047424034.1 → XP_047279990.1  multiple PDZ domain protein isoform X6

    21. XM_047424023.1 → XP_047279979.1  multiple PDZ domain protein isoform X4

    22. XM_047424009.1 → XP_047279965.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    23. XM_047424022.1 → XP_047279978.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    24. XM_054328427.1 → XP_054184402.1  multiple PDZ domain protein isoform X7

    25. XM_047424012.1 → XP_047279968.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    26. XM_047424036.1 → XP_047279992.1  multiple PDZ domain protein isoform X8

    27. XM_047424024.1 → XP_047279980.1  multiple PDZ domain protein isoform X4

    28. XM_047424010.1 → XP_047279966.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    29. XM_047424026.1 → XP_047279982.1  multiple PDZ domain protein isoform X4

    30. XM_047424014.1 → XP_047279970.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    31. XM_047424020.1 → XP_047279976.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    32. XM_047424019.1 → XP_047279975.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    33. XM_047424018.1 → XP_047279974.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    34. XM_047424038.1 → XP_047279994.1  multiple PDZ domain protein isoform X8

    35. XM_047424029.1 → XP_047279985.1  multiple PDZ domain protein isoform X4

    36. XM_047424017.1 → XP_047279973.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    37. XM_047424027.1 → XP_047279983.1  multiple PDZ domain protein isoform X4

    38. XM_047424041.1 → XP_047279997.1  multiple PDZ domain protein isoform X8

    39. XM_047424032.1 → XP_047279988.1  multiple PDZ domain protein isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      13115022..13289091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364122.1 → XP_054220097.1  multiple PDZ domain protein isoform X7

    2. XM_054364112.1 → XP_054220087.1  multiple PDZ domain protein isoform X4

    3. XM_054364100.1 → XP_054220075.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    4. XM_054364115.1 → XP_054220090.1  multiple PDZ domain protein isoform X4

    5. XM_054364098.1 → XP_054220073.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    6. XM_054364119.1 → XP_054220094.1  multiple PDZ domain protein isoform X5

    7. XM_054364108.1 → XP_054220083.1  multiple PDZ domain protein isoform X2

    8. XM_054364109.1 → XP_054220084.1  multiple PDZ domain protein isoform X3

    9. XM_054364131.1 → XP_054220106.1  multiple PDZ domain protein isoform X8

    10. XM_054364102.1 → XP_054220077.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    11. XM_054364121.1 → XP_054220096.1  multiple PDZ domain protein isoform X6

    12. XM_054364095.1 → XP_054220070.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    13. XM_054364129.1 → XP_054220104.1  multiple PDZ domain protein isoform X8

    14. XM_054364127.1 → XP_054220102.1  multiple PDZ domain protein isoform X8

    15. XM_054364132.1 → XP_054220107.1  multiple PDZ domain protein isoform X8

    16. XM_054364101.1 → XP_054220076.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    17. XM_054364130.1 → XP_054220105.1  multiple PDZ domain protein isoform X8

    18. XM_054364117.1 → XP_054220092.1  multiple PDZ domain protein isoform X4

    19. XM_054364125.1 → XP_054220100.1  multiple PDZ domain protein isoform X8

    20. XM_054364120.1 → XP_054220095.1  multiple PDZ domain protein isoform X6

    21. XM_054364110.1 → XP_054220085.1  multiple PDZ domain protein isoform X4

    22. XM_054364094.1 → XP_054220069.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    23. XM_054364107.1 → XP_054220082.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    24. XM_054364123.1 → XP_054220098.1  multiple PDZ domain protein isoform X7

    25. XM_054364097.1 → XP_054220072.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    26. XM_054364124.1 → XP_054220099.1  multiple PDZ domain protein isoform X8

    27. XM_054364111.1 → XP_054220086.1  multiple PDZ domain protein isoform X4

    28. XM_054364096.1 → XP_054220071.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    29. XM_054364113.1 → XP_054220088.1  multiple PDZ domain protein isoform X4

    30. XM_054364099.1 → XP_054220074.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    31. XM_054364106.1 → XP_054220081.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    32. XM_054364105.1 → XP_054220080.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    33. XM_054364104.1 → XP_054220079.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    34. XM_054364126.1 → XP_054220101.1  multiple PDZ domain protein isoform X8

    35. XM_054364116.1 → XP_054220091.1  multiple PDZ domain protein isoform X4

    36. XM_054364103.1 → XP_054220078.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

    37. XM_054364114.1 → XP_054220089.1  multiple PDZ domain protein isoform X4

    38. XM_054364133.1 → XP_054220108.1  multiple PDZ domain protein isoform X9

    39. XM_054364128.1 → XP_054220103.1  multiple PDZ domain protein isoform X8

    40. XM_054364118.1 → XP_054220093.1  multiple PDZ domain protein isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75970.2 GenPept UniProtKB/Swiss-Prot:O75970

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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