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    LOC127273650 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:71727399-71728077 [ Homo sapiens (human) ]

    Gene ID: 127273650, updated on 12-Sep-2024

    Summary

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    Gene symbol
    LOC127273650
    Gene description
    H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:71727399-71728077
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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    Genomic context

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    See LOC127273650 in Genome Data Viewer
    Location:
    chromosome: 2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (71500269..71500947)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (71511390..71512068)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (71727399..71728077)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16018 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71558505-71559192 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71559193-71559878 Neighboring gene Sharpr-MPRA regulatory region 7735 Neighboring gene zinc finger protein 638 Neighboring gene RNA, U6 small nuclear 105, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:71643743-71644372 Neighboring gene Sharpr-MPRA regulatory region 6666 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71672359-71672860 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:71678052-71678238 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:71680549-71681398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:71681399-71682247 Neighboring gene VISTA enhancer hs2170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71730437-71730936 Neighboring gene Sharpr-MPRA regulatory region 7639 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71733683-71734184 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71734185-71734684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71739143-71739642 Neighboring gene NANOG hESC enhancer GRCh37_chr2:71754884-71755402 Neighboring gene dysferlin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71780379-71780878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71779877-71780378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:71787253-71787780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71813506-71814014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71814015-71814523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71815560-71816140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71821207-71821706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71825151-71825652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71825653-71826152 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:71829831-71831030 Neighboring gene VISTA enhancer hs1479 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:71920591-71921090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:71921091-71922090 Neighboring gene uncharacterized LOC124907827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72018477-72019464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72021448-72022059 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:72057331-72058530 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:72070213-72070395 Neighboring gene Sharpr-MPRA regulatory region 1897 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:72107588-72108787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72120471-72120972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72120973-72121472 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:72124986-72125167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72157000-72157500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72159067-72159946 Neighboring gene ribosomal protein S20 pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_095501.1 

      Range
      101..779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      71500269..71500947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      71511390..71512068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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