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    LOC127889525 NANOG-H3K27ac hESC enhancer GRCh37_chr18:68034191-68034901 [ Homo sapiens (human) ]

    Gene ID: 127889525, updated on 10-Oct-2023

    Summary

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    Gene symbol
    LOC127889525
    Gene description
    NANOG-H3K27ac hESC enhancer GRCh37_chr18:68034191-68034901
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac histone modification. [provided by RefSeq, Dec 2022]
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    Genomic context

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    See LOC127889525 in Genome Data Viewer
    Location:
    chromosome: 18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (70366955..70367665)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (70582065..70582775)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9540 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:67960199-67960375 Neighboring gene suppressor of cytokine signaling 6 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:68004081-68005280 Neighboring gene long intergenic non-protein coding RNA 1909 Neighboring gene liver cell viability associated lncRNA Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:68015472-68016064 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:68024559-68025758 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:68033479-68034190 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:68051227-68052426 Neighboring gene long intergenic non-protein coding RNA 1910 Neighboring gene LARP7 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_139049.1 

      Range
      101..811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      70366955..70367665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      70582065..70582775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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