Genome

Plasmodium falciparum (malaria parasite P. falciparum) One of the causal agents of human malaria Lineage: Eukaryota[15557]; Sar[553]; Alveolata[174]; Apicomplexa[80]; Aconoidasida[41]; Haemosporida[23]; Plasmodiidae[22]; Plasmodium[21]; Plasmodium (Laverania)[4]; Plasmodium falciparum[1]

The protozoan parasite Plasmodium falciparum is the causal agent of human malaria. This parasite has a very complex lifecycle, involving vertebrate and invertebrate hosts. Infective forms (sporozoites) are transmitted to the human host during the mosquito Anopheles' blood meal. Malaria is a devastating parasitic disease; it infects 300 More...million people and kills up to three million people per year. More than half of the world population lives in areas where malaria is endemic. Malaria represents one of the most important public health problems worldwide. The parasite has developed resistance to anti-malarials and the mosquito hosts have developed resistance to insecticides. Less...

Summary Sequence data:  genome assemblies: 65; sequence reads: 155  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 23.4808  median protein count: 5929  median GC%: 19.8 Publications (limited to 20 most recent records) Antigenic diversity in malaria parasites is maintained on extrachromosomal DNA. Ebel ER, et al. bioRxiv 2023 Feb 2 Progression of the canonical reference malaria parasite genome from 2002-2019. Böhme U, et al. Wellcome Open Res 2019 A genome-wide map of diversity in Plasmodium falciparum. Volkman SK, et al. Nat Genet 2007 Jan Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature 2002 Oct 3 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature 2002 Oct 3 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, et al. Nature 2002 Oct 3 Sequence of Plasmodium falciparum chromosome 12. Hyman RW, et al. Nature 2002 Oct 3 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, et al. Nature 1999 Aug 5 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Science 1998 Nov 6 More...  Representative (genome information for reference and representative genomes) Reference genome:   Plasmodium falciparum 3D7 Submitter: Plasmodium falciparum Genome Sequencing Consortium Loc Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene Chr 1 NC_004325.2 AL844501.2 0.64 20.5 136 5 - 5 158 14 Chr 2 NC_037280.1 LN999943.1 0.95 19.7 219 - 1 5 234 14 Chr 3 NC_000521.4 AL844502.2 1.07 20.1 241 - 2 4 249 4 Chr 4 NC_004318.2 AL844503.2 1.2 20.5 235 - 5 6 261 18 Chr 5 NC_004326.2 AL844504.2 1.34 19.3 313 5 5 2 332 10 Chr 6 NC_004327.3 AL844505.2 1.42 19.8 321 - 3 3 332 10 Chr 7 NC_004328.3 AL844506.3 1.45 19.8 293 5 11 7 331 15 Chr 8 NC_004329.3 AL844507.3 1.47 19.6 319 4 - 11 341 9 Chr 9 NC_004330.2 AL844508.2 1.54 19.0 384 - - 2 382 4 Chr 10 NC_037281.1 LN999944.1 1.69 19.6 410 - - - 408 9 Chr 11 NC_037282.1 LN999945.1 2.04 19.0 480 3 2 16 503 11 Chr 12 NC_037284.1 LN999947.1 2.27 19.3 532 - 3 11 552 12 Chr 13 NC_004331.3 AL844509.3 2.93 19.0 698 3 10 12 730 12 Chr 14 NC_037283.1 LN999946.1 3.29 18.4 773 3 3 18 802 16 Chromosomes Click on chromosome name to open Genome Data Viewer External Resources BioResearch (BIORES) DFCI P.falciparum Gene Index Ensembl/Protists Malaria Foundation PlasmoDB Plasmodium falciparum GeneDB Stanford Genome Technology Center - Malaria Genome Project TIGR - The Plasmodium falciparum Genome Database (PFDB) The Sanger Institute: Plasmodium falciparum Genome Project WHO/TDR Malaria Database