Genome

Encephalitozoon cuniculi An obligate intracellular parasite at the base of Kingdom Fungi. Lineage: Eukaryota[15557]; Fungi[5220]; Fungi incertae sedis[363]; Microsporidia[54]; Unikaryonidae[4]; Encephalitozoon[4]; Encephalitozoon cuniculi[1]

Encephalitozoon cuniculi is a single-celled, intracellular parasite that belongs to the Phylum Microsporidia and has no mitochondrion. It infects a range of mammals, in humans, it causes a variety of conditions affecting the nervous system, respiratory and digestive tracts. Like all microsporidia, E. cuniculi lacks mitochondria, infects More...the host with a polar filament and survives as microsporidia outside the host.Although microsporidia were once thought to have evolved from an ancient eukaryotic lineage before the acquisition of mitochondria, there is growing evidence that they are more related to fungi. Analysis of the E. cuniculi genome supports this fungal association: it contains genes of putative mitochondrial origin, suggesting that E. cuniculi has retained a mitochondrion-derived organelle, and phylogenetic studies of several genes placed E. cuniculi sister to fungi or within the fungal Kingdom.E. cuniculi has one of the smallest known eukaryotic genomes, approximately 2.9 Mb. Its genome is organized in 11 chromosomes and has approximately 2,000 predicted protein-encoding genes. Less...

Summary Sequence data:  genome assemblies: 6; sequence reads: 1  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 2.28811  median protein count: 2122  median GC%: 46.9 Publications (limited to 20 most recent records) The genome of an Encephalitozoon cuniculi type III strain reveals insights into the genetic diversity and mode of reproduction of a ubiquitous vertebrate pathogen. Pelin A, et al. Heredity (Edinb) 2016 May Complete genome sequences from three genetically distinct strains reveal high intraspecies genetic diversity in the microsporidian Encephalitozoon cuniculi. Pombert JF, et al. Eukaryot Cell 2013 Apr Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation. Peyretaillade E, et al. BMC Genomics 2009 Dec 15 Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi. Katinka MD, et al. Nature 2001 Nov 22 More...  Representative (genome information for reference and representative genomes) Reference genome:   Encephalitozoon cuniculi GB-M1 Submitter: Genoscope Loc Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Chr I NC_003242.2 AL391737.2 0.21 49.3 162 4 2 - 168 Chr II NC_003229.1 AL590442.1 0.2 46.6 169 - 5 - 169 Chr III NC_003230.1 AL590443.1 0.19 46.9 166 - 4 - 166 Chr IV NC_003231.1 AL590444.1 0.22 47.2 188 - 6 - 188 Chr V NC_003232.1 AL590445.1 0.21 46.7 180 1 2 - 183 Chr VI NC_003233.1 AL590446.1 0.22 47.3 186 - 4 1 191 Chr VII NC_003234.1 AL590447.1 0.23 47.2 200 1 5 - 206 Chr VIII NC_003235.1 AL590448.1 0.24 47.8 223 - 7 1 224 Chr IX NC_003238.2 AL590451.2 0.25 46.7 220 1 3 - 224 Chr X NC_003236.1 AL590449.1 0.26 47.3 200 - 5 - 205 Chr XI NC_003237.2 AL590450.2 0.27 47.3 228 - 3 - 231 Chromosomes Click on chromosome name to open Genome Data Viewer External Resources Genoscope