Genome

Streptococcus pyogenes Causes tonsilitis Lineage: Bacteria[37515]; Bacillota[6135]; Bacilli[2619]; Lactobacillales[872]; Streptococcaceae[167]; Streptococcus[127]; Streptococcus pyogenes[1]

Streptococci. Streptococci are Gram-positive, nonmotile, nonsporeforming, catalase-negative cocci that occur in pairs or chains. Members of this genus vary widely in pathogenic potential. Most streptococci are facultative anaerobes, and some are obligate anaerobes. The genus is classified on the basis of colony morphology, hemolysis, biochemical More...reactions, and serologic specificity. They are divided into three groups by the type of hemolysis on blood agar plates: beta-hemolytic, alpha-hemolytic or gamma-hemolytic. Serologic grouping is based on antigenic differences in cell wall carbohydrates, in cell wall pili-associated protein, and in the polysaccharide capsule in group B streptococci. Streptococcus pyogenes. This organism is a member of the normal human nasopharyngeal flora. S. pyogenes is a group A streptococcus and is the leading cause of uncomplicated bacterial pharyngitis and tonsillitis. Infections can also result in sinusitis, otitis, mastoiditis, pneumonia with empyema, joint or bone infections, necrotizing fasciitis or myositis, and, more infrequently, in meningitis or endocarditis. S. pyogenes infections of the skin can be superficial (impetigo) or deep (cellulitis). This organism is commonly referred to by the lay press as "flesh eating bacteria." Less...

Summary Sequence data:  genome assemblies: 2278; sequence reads: 186  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 1.79141  median protein count: 1665  median GC%: 38.4 Publications (limited to 20 most recent records) Streptolysin S is required for Streptococcus pyogenes nasopharyngeal and skin infection in HLA-transgenic mice. Shannon BA, et al. PLoS Pathog 2024 Mar Increase in invasive Streptococcus pyogenes M1 infections with close evolutionary genetic relationship, Iceland and Scotland, 2022 to 2023. Beres SB, et al. Euro Surveill 2024 Mar M1(UK)Streptococcus pyogenes causing community-acquired pneumonia, pleural empyema and streptococcal toxic shock syndrome. Mavroidi A, et al. J Glob Antimicrob Resist 2024 Jun A Streptococcus pyogenes DegV protein regulates the membrane lipid content and limits the formation of extracellular vesicles. Lambert C, et al. PLoS One 2023 High-level levofloxacin-resistant emm12 group A Streptococcus, 2012-2018: A multicenter study in Taiwan. Huang YC, et al. J Microbiol Immunol Infect 2023 Aug The Streptococcus pyogenes hyaluronic acid capsule promotes experimental nasal and skin infection by preventing neutrophil-mediated clearance. Hurst JR, et al. PLoS Pathog 2022 Nov Cryptic prophages within a Streptococcus pyogenes genotype emm4 lineage. Remmington A, et al. Microb Genom 2021 Jan Detection of Epidemic Scarlet Fever Group A Streptococcus in Australia. Walker MJ, et al. Clin Infect Dis 2019 Sep 13 Superantigen SpeA attenuates the biofilm forming capacity of Streptococcus pyogenes. Babbar A, et al. J Microbiol 2019 Jul Remarkable Genome Stability among emm1 Group A Streptococcus in Belgium over 19 Years. Coppens J, et al. Genome Biol Evol 2019 May 1 FDA-ARGOS is a database with public quality-controlled reference genomes for diagnostic use and regulatory science. Sichtig H, et al. Nat Commun 2019 Jul 25 EBI Metagenomics in 2017: enriching the analysis of microbial communities, from sequence reads to assemblies. Mitchell AL, et al. Nucleic Acids Res 2018 Jan 4 Draft Genome Sequence of Streptococcus canis Clinical Strain TA4, Harboring the M-Like Protein Gene and Isolated in Japan from a Patient with Bacteremia. Yoshida H, et al. Genome Announc 2018 Jan 18 Canada-Wide Epidemic of emm74 Group A Streptococcus Invasive Disease. Teatero S, et al. Open Forum Infect Dis 2018 May Importance of whole genome sequencing for the assessment of outbreaks in diagnostic laboratories: analysis of a case series of invasive Streptococcus pyogenes infections. Tagini F, et al. Eur J Clin Microbiol Infect Dis 2017 Jul Draft Genome Sequence of Clinical Strain TANI1 of Streptococcus suis Serotype 5 Isolated from a Bacteremia Patient in Japan. Yoshida H, et al. Genome Announc 2017 May 4 An emm5 Group A Streptococcal Outbreak Among Workers in a Factory Manufacturing Telephone Accessories. Chen M, et al. Front Microbiol 2017 Complete Genome Sequence of emm4 Streptococcus pyogenes MEW427, a Throat Isolate from a Child Meeting Clinical Criteria for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS). Jacob KM, et al. Genome Announc 2016 Mar 17 Complete Genome Sequence of emm28 Type Streptococcus pyogenes MEW123, a Streptomycin-Resistant Derivative of a Clinical Throat Isolate Suitable for Investigation of Pathogenesis. Jacob KM, et al. Genome Announc 2016 Mar 17 Human case of bacteremia due to Streptococcus suis serotype 5 in Japan: The first report and literature review. Taniyama D, et al. IDCases 2016 More...  Representative (genome information for reference and representative genomes) Reference genome:   Streptococcus pyogenes 41965_F01 Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene Chr 1 NZ_LS483338.1 LS483338.1 1.75 38.5 1,601 18 67 4 1,722 32 Dendrogram (based on genomic BLAST) External Resources NMPDR