Comprehensive characterisation of HNF4A and HNF1A genomic targets in pancreatic beta cells and hepatic cells reveals common and tissue-specific pathways and genes

PAX4 loss of function alters human endocrine cell development and influences diabetes risk [dateset 1]

PAX4 loss of function alters human endocrine cell development and influences diabetes risk [dataset 2]

PAX4 loss of function alters human endocrine cell development and influences diabetes risk.

ERK1/2 signaling is necessary for definitive endoderm formation

Identification of HNF1A targets in WT hPSC-derived kidney organoids

Metformin-treated hESC-derived pancreatic organoids

Progressive ER stress over time due to human insulin gene mutation contributes to pancreatic β-cell dysfunction, islet inflammation and compensatory responses

Decreased GLUT2 expression and defective glucose uptake in MODY3 human iPSC-Derived beta cells

Decreased GLUT2 expression and defective glucose uptake in MODY3 human iPSC-derived beta cells

BCL-xL/BCL2L1 is a critical anti-apoptotic protein that suppresses BAK to promote pancreatic specification from human pluripotent stem cells

Loss-of-function due to MODY1/HNF4A mutation abrogates liver and pancreas differentiation from MODY1-hiPSCs