Genome-wide in vivo dynamics of cohesin-mediated loop extrusion and its role in transcription activation [Hi-C]

Genome-wide in vivo dynamics of cohesin-mediated loop extrusion and its role in transcription activation

Fast Low-Input Efficient Hi-C

Large-scale manipulation of radial positioning does not affect most aspects of genome organization

Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architecture

Obtention of viable cell suspensions from breast cancer tumor biopsies for 3D chromatin conformation and single cell transcriptome analysis [Hi-C]

Obtention of viable cell suspensions from breast cancer tumor biopsies for 3D chromatin conformation and single cell transcriptome analysis

Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13) [HiC]

Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)

Deterioration of multi-level 3D genome organization during breast cancer progression

Universal dynamics of cohesin-mediated loop extrusion

TULIPs decorate the three-dimensional genome of PFA ependymoma

UV-induced reorganization of 3D genome mediates DNA damage response [Hi-C]

CRL4-DCAF15 control of cohesin dynamics sustains cell proliferation [HiC]

Estradiol-dependent 3D chromatin structure changes in MCF7 cells assessed by Capture-C, covering GREB1 and NRIP1 gene and enhancer regions

CRISPR Screening Uncovers a Long-Range Enhancer for ONECUT1 in Pancreatic Differentiation and Links a Diabetes Risk Variant [Hi-C]

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [microC]

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor

Extensive long-range polycomb interactions and weak compartmentalization are hallmarks of human neuronal 3D genome

Extreme structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs [Hi-C]