Patient derived pancreatic cancer organoids p53R175H ON Replicate 1

Patient derived pancreatic cancer organoids p53R175H ON Replicate 2

Patient derived pancreatic cancer organoids p53R175H ON Replicate 3

Patient derived pancreatic cancer organoids p53R175H OFF shRNA1 Replicate 1

Patient derived pancreatic cancer organoids p53R175H OFF shRNA1 Replicate 2

Patient derived pancreatic cancer organoids p53R175H OFF shRNA1 Replicate 3

Patient derived pancreatic cancer organoids p53R175H OFF shRNA2 Replicate 1

Patient derived pancreatic cancer organoids p53R175H OFF shRNA2 Replicate 2

Patient derived pancreatic cancer organoids p53R175H OFF shRNA2 Replicate 3

Murine pancreatic cancer cell line p53R172H shRNA1 OFF Replicate 1

Murine pancreatic cancer cell line p53R172H shRNA1 OFF Replicate 2

Murine pancreatic cancer cell line p53R172H shRNA1 OFF Replicate 3

Murine pancreatic cancer cell line p53R172H ON Replicate 1

Murine pancreatic cancer cell line p53R172H ON Replicate 2

Murine pancreatic cancer cell line p53R172H ON Replicate 3

Murine pancreatic cancer cell line p53R172H shshRNA2 OFF Replicate 1

Murine pancreatic cancer cell line p53R172H shshRNA2 OFF Replicate 2

Murine pancreatic cancer cell line p53R172H shshRNA2 OFF Replicate 3

Murine pancreatic cancer cell line p53R172H ON Replicate 4

Murine pancreatic cancer cell line p53R172H ON Replicate 5