Human FLI1-binding sites in wild-type hematopoietic progenitor cells

Human FLI1-binding sites in HPCs with RUNX1-Y287X heterozygous mutation and transfected empty vector (pCW57.1-FLI1)

Human FLI1-binding sites in HPCs with RUNX1-Y287X heterozygous mutation and transfected vector expressing WT FLI1

Input DNA fragments of wild-type hematopoietic progenitor cells

Input DNA fragments of HPCs with RUNX1-Y287X heterozygous mutation and transfected empty vector (pCW57.1-FLI1)

Input DNA fragments of HPCs with RUNX1-Y287X heterozygous mutation and transfected vector expressing WT FLI1

Wild-type CD34+CD45+ HPCs, rep1, EM-seq

Wild-type CD34+CD45+ HPCs, rep2, EM-seq

CD34+CD45+ HPCs with RUNX1-R201Q heterozygous mutation, rep1, EM-seq

CD34+CD45+ HPCs with RUNX1-R201Q heterozygous mutation, rep2, EM-seq

CD34+CD45+ HPCs with RUNX1-Y287X heterozygous mutation, rep1, EM-seq

CD34+CD45+ HPCs with RUNX1-Y287X heterozygous mutation, rep2, EM-seq

DOX-minus iPS cells, EM-seq

DOX-inducible FLI1-overexpressing iPS cells, EM-seq

Wild-type iPS cells, WES

iPS cells with RUNX1-R201Q heterozygous mutation, WES

iPS cells with RUNX1-Y287X heterozygous mutation, WES

CD34+CD45+ HPCs with RUNX1-Y287X heterozygous mutation as mock-control, EM-seq

FLI1-overexpressing CD34+CD45+ HPCs with RUNX1-Y287X heterozygous mutation, EM-seq