Opposing tumor cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in anti-tumor immunity

Endonucleolytic RNA cleavage drives changes in gene expression during the innate immune response

Endonucleolytic RNA cleavage drives changes in gene expression during the innate immune response [ribosome profiling]

ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models

Development and validation of AI/ML derived splice-switching oligonucleotides

TCAF1 Promotes TRPV2-mediated Ca2+ Release in Response to Cytosolic DNA to Protect Stressed Replication Forks

Activation of MEK‐ERK‐c‐MYC signaling pathway promotes splenic M2 macrophage polarization to inhibit PHcH-liver cirrhosis

Reduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters [ChIP-Seq]

Reduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters

The SAGA complex maintains the oncogenic gene expression program in MYCN-amplified neuroblastoma [RNA-Seq]

The SAGA complex maintains the oncogenic gene expression program in MYCN-amplified neuroblastoma

XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells

Combined bioinformatic and clinical assay uncovers resistance and susceptibility mechanisms of human glioblastomas to temozolomide and identifies new survival biomarkers outperforming MGMT promoter methylation

Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma

DUSP6 inhibition overcomes Neuregulin/HER3-driven therapy resistance in HER2+ breast cancer [BT474]

DUSP6 inhibition overcomes Neuregulin/HER3-driven therapy resistance in HER2+ breast cancer

MYCT1 Controls Environmental Sensing in human Hematopoietic Stem Cells [RNA-seq]

MYCT1 Controls Environmental Sensing in human Hematopoietic Stem Cells.

Regulation of mRNA translation by RNH1 in hematopoietic cells

Alternative polyadenylation is a minor feature of primary human muscle differentiation