MRI and gene signatures in facioscapulohumeral dystrophy muscle: implications for clinical trial design and mechanisms of disease progression

DUX4 orchestrates translational reprograming by broadly suppressing translation efficiency [polysome-seq]

DUX4 orchestrates translational reprograming by broadly suppressing translation efficiency [Ribo-seq]

DUX4 orchestrates translational reprograming by broadly suppressing translation efficiency [RNA-seq]

The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs

Canine DUXC isoforms and functional similarity to human DUX4 [ChIP-seq]

Canine DUXC isoforms and functional similarity to human DUX4 [RNA-seq]

Canine DUXC isoforms and functional similarity to human DUX4

Longitudinal measures of RNA expression and disease activity in FSHD muscle biopsies

DUX4-induced transcripts from pericentric human satellite II repeats form double-stranded RNA [dsRIPseq]

DUX4-induced transcripts from pericentric human satellite II repeats form double-stranded RNA [stranded-RNAseq]

DUX4-induced transcripts from pericentric human satellite II repeats form double-stranded RNA

DUX4-induced histone variants H3.X and H3.Y mark DUX4 target genes for expression (CUT&RUN)

DUX4-induced histone variants H3.X and H3.Y mark DUX4 target genes for expression (RNA-seq)

DUX4-induced histone variants H3.X and H3.Y mark DUX4 target genes for expression

MRI-informed muscle biopsies correlate MRI with pathology and DUX4 target gene expression in FSHD

Small noncoding RNAs in FSHD2 muscle cells reveal both DUX4- and SMCHD1-specific signatures

Conservation and innovation in the DUX4-family gene network (RNA-seq)

Conservation and innovation in the DUX4-family gene network (ChIP-seq)

Conservation and innovation in the DUX4-family gene network