Combinatorial genetics reveals the DOCK1-RAC2 axis as a specific target for the treatment of NPM1;Cohesin mutated AML

Two super-enhancers regulate Nanog expression through distinct mechanisms [45del]

Defining a critical Nanog enhancer using chromatin-focused approaches identifies RNAPII recruitment as required for expression [-5delRNASeq]

Defining a critical Nanog enhancer using chromatin-focused approaches identifies RNAPII recruitment as required for expression [CUT&Tag]

Genome editing demonstrates that the -5 kb Nanog enhancer regulates Nanog expression by modulating RNAPII initiation and/or recruitment

Defining a critical Nanog enhancer using chromatin-focused approaches identifies RNAPII recruitment as required for expression [ATAC-Seq]

Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation

RNA-seq of WT, Tet1-/-, Tet2-/-, Tet1-/-:Tet2-/- (DKO), and Tet1-/-:Tet2-/-:Tet3-/- (TKO) murine embryonic stem cells following six days of LIF withdrawal.

Reduced representation bisulfite sequencing (RRBS) of WT, Tet1-/-, Tet2-/-, Tet1-/-:Tet2-/- (DKO), and Tet1-/-:Tet2-/-:Tet3-/- (TKO) murine embryonic stem under normal culture conditions.

Functional genomic analysis of WT, Tet1-/-, Tet2-/-, Tet1-/-:Tet2-/- (DKO) murine embryonic stem cells

RNA-seq analysis of splenic follicular IgD low and IgD high, and marginal zone B cells

Identification of differential gene expression in WT and DGKzeta deficient CD8 T cells by RNA-seq

RNA-sequencing of murine wildtype and E2F-2 knockout hematopoietic progenitors and mature erythroblasts

Cohesin in AML

The cohesin offloading factor Wapal is required for proper polycomb-mediated gene silencing [array]

The cohesin offloading factor Wapal is required for proper polycomb-mediated gene silencing [ChIP-Seq]

The cohesin associated factor Wapal is required for proper polycomb-mediated gene silencing

The cohesin associated protein Wapal is required for proper polycomb-mediated gene silencing [Ring1b ChIP-seq]