RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation.

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity

The PAX5-JAK2 translocation acts as a dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation

Rec8 ChIP-seq for wild type, eco1-aa, wpl1Δ and eco1-aa wpl1Δ strains arrested in meiotic prophase I

Calibrated Smc3 ChIP-seq for wild type, eco1-aa, wpl1-delta and eco1-aa wpl1-delta strains arrested in meiotic prophase I

Calibrated Smc3 ChIP-seq for wild type, smc3-2R, wpl1Δ and smc3-2R wpl1Δ strains arrested in meiotic prophase I

Eco1-dependent cohesin acetylation anchors chromatin loops and cohesion to define functional meiotic chromosome domains

Chromosome conformation for wild type and clb5 clb6 strains arrested before meiotic S phase

Calibrated Smc3 ChIP-seq for wild type, eco1-aa, cdc6-mn and eco1-aa cdc6-mn strains arrested in meiotic prophase I

Chromosome conformation for wild type, eco1-aa, cdc6-mn and eco1-aa cdc6-mn strains arrested in meiotic prophase I