A three-dimensional map of the human genome at kilobase resolution reveals prinicples of chromatin looping

Deletion of DXZ4 on the human inactive X chromosome eliminates superdomains and impairs gene silencing

Distinct Enhancer Classes in Drosophila Bind Different Architectural Proteins and Mediate Unique Chromatin Interactions and 3D Architecture [Hi-C]

HiChIP: Efficient and sensitive analysis of protein-directed genome architecture

Myc regulates chromatin decompaction and nuclear architecture during B cell activation

Sub-kilobase resolution Kc167 cell Hi-C

Evolutionary Principles Predict 3D Chromatin Organization

Hi-C from A549 (ENCSR244BBG)

Hi-C from A549 (ENCSR393LOP)

Hi-C from A549 (ENCSR499RVD)

Hi-C from A549 (ENCSR662QKG)

Hi-C from A549 (ENCSR757IVO)

Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation

The nuclear matrix associating protein HNRNPU functions as a key regulator of 3D genome architecture [Hi-C]

The nuclear matrix associating protein HNRNPU functions as a key regulator of 3D genome architecture

Loss of CTCF reveals basic properties of post-mitotic epigenomes and induces heart failure [HiC-seq]

Loss of CTCF reveals basic properties of post-mitotic epigenomes and induces heart failure

The energetics and physiological impact of cohesin extrusion

Chromatin structure and CTCF across the MCF10 breast cancer progression series (HiC)

Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL and PDS5 proteins