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Platform GPL112 Query DataSets for GPL112
Status Public on Apr 03, 2002
Title NIA Signal Transduction Array
Technology type spotted DNA/cDNA
Distribution non-commercial
Organism Homo sapiens
 
Description The NIA Signal Transduction Array is a focused 1152-clone cDNA microarray designed specifically to investigate signal transduction pathways.
Full details of clone preparation, printing, hybridization, image capture, and spot quantification protocols for this array can be found at the web link below.
The array was last annotated March 2002.
Keywords = signal transduction, pathways
 
Web link http://www.grc.nia.nih.gov/branches/rrb/dna/neuroscience.pdf
Contributor(s) Cheadle C, Wood WH, Becker KG
Submission date Mar 18, 2002
Last update date Jun 22, 2020
Contact name Supriyo De
Organization name NIA-IRP, NIH
Department Laboratory of Genetics and Genomics
Lab Computational Biology & Genomics Core
Street address 251 Bayview Blvd
City Baltimore
State/province Maryland
ZIP/Postal code 21224
Country USA
 

Data table header descriptions
ID
GENE_NAME gene name
GENE_SYM gene symbol
GB_ACC GenBank accession number
UNIGENE
GENE Entrez GENE ID
CYTOBAND cytoband
EXP_AREA expression area
CLONE_ID IMAGE clone ID
SP_ID
SP_SUBCELL_LOC SwissProt subcellular location
SP_PROT_FAM_DESC SwissProt protein family description
SP_PROT_FUNCTION SwissProt protein function
SP_KEYWORDS SwissProt keywords
MEDLINE_ARTICLES Medline articles
GRID_POS microarray grid position
PIN_NO microarrayer pin number
PLATE clone plate number
ROW clone plate row
COLUMN clone plate column

Data table
ID GENE_NAME GENE_SYM GB_ACC UNIGENE GENE CYTOBAND EXP_AREA CLONE_ID SP_ID SP_SUBCELL_LOC SP_PROT_FAM_DESC SP_PROT_FUNCTION SP_KEYWORDS MEDLINE_ARTICLES GRID_POS PIN_NO PLATE ROW COLUMN
1 amplified in osteosarcoma OS-9 AA013336 76228 10956 12q13 "fetal liver/spleen;HeLa (cell line);prostate (tumor);ovary;retina;fetal heart;pancreatic islets;prostate (preneoplastic);fetal spleen;aorta;liver;colon;ovary (tumor);fetal brain;infant brain;brain--cerebellum;colorectal (tumor);fetal lung;placenta;colon (carcinoma, cell line HCC);fibrosarcoma;T cells (Jurkat cell line);fibroblast;pineal gland;thymus gland;epididymus;testis;T cells (activated)" 360079 GRID- 1-R1C1 2 2 a 12
2 TNF receptor-associated factor 6 TRAF6 AA456692 90957 7189 11p12 placenta;fetal liver/spleen;embryo (9 week) 813166 GRID- 1-R2C1 2 2 a 10
3 ubiquitin carrier protein E2-C UBCH10 AA430504 93002 11065 20q13.12 fetal liver/spleen;colon;lung (carcinoma);fetal brain;fetal heart;ovary (tumor);placenta;testis;T cells (Jurkat cell line) 769921 GRID- 1-R3C1 2 2 a 8
4 "inositol 1,3,4-triphosphate 5/6 kinase" ITPK1 AA464067 6453 3705 14q31 brain;ovary (tumor);infant brain;placenta;fetal liver/spleen;multiple sclerosis lesions;uterus (pregnant);fetal heart;fetal lung;brain--cerebellum;liver;breast;heart 810282 GRID- 1-R4C1 2 2 a 6
5 "interleukin 11 receptor, alpha" IL11RA AA456272 64310 3590 9p13 colon;retina;fetal liver/spleen;skeletal muscle;fetal lung;parathyroid gland (tumor);breast;embryonic placenta;ovary 811920 GRID- 1-R5C1 2 2 a 4
6 "RAB31, member RAS oncogene family" RAB31 T96083 223025 11031 18p11.3 infant brain;uterus (pregnant);fetal liver/spleen;fetal heart;HeLa (cell line);placenta;lung;olfactory epithelium;brain;aorta;brain--left hemisphere;embryo (12 week);melanocyte;embryo (6 week);multiple sclerosis lesions;breast;testis;pineal gland;fetal lung;testis (tumor);colon;ovary (tumor);bone 120881 Q15770 Ras-related protein Rab-31 (Rab-22B). "GTP-binding, Lipoprotein, Prenylation" 97017138 GRID- 1-R6C1 2 2 a 2
7 "interferon-stimulated transcription factor 3, gamma (48kD)" ISGF3G AA291577 1706 10379 14q11.2 placenta;ovary (tumor);parathyroid gland (tumor);colon;pineal gland 724588 Q00978 Nuclear. Transcriptional regulator ISGF3 gamma subunit (IFN-alpha responsivetranscription factor subunit) (Interferon stimulated gene factor 3gamma) (ISGF3 p48 subunit) (ISGF-3 gamma). "RESPONSIBLE FOR THE INITIAL STIMULATION OF INF-ALPHA- RESPONSIVE GENES. IT RECOGNIZES AND BINDS TO THE INF-STIMULATED RESPONSE ELEMENT, OR ISRE WITHIN THE REGULATORY SEQUENCES OF TARGET GENES. ISGF3 PLAYS A PRIMARY ROLE IN THE TRANSMISSION OF A SIGNAL FROM THE CELL SURFACE TO THE NUCLEUS." "Activator, DNA-binding, Interferon induction, Nuclear protein, Transcription regulation" 92334329 GRID- 1-R7C1 2 1 a 12
8 TYROSINE-PROTEINKINASEITK/TSK KIAA1046 R78541 89519 22867 4q31.1 fetal liver/spleen;placenta;testis;B-Cell;melanocyte;pancreas;muscle;fetal lung;pancreas (tumor cell line);liver;prostate 144867 GRID- 1-R8C1 2 1 a 10
9 nuclear factor (erythroid-derived 2)-like 1 NFE2L1 AA496576 83469 4779 17q21.3 fetal heart;melanocyte;uterus (pregnant);infant brain;NT2 neuronal precursor;fetal liver/spleen;breast;fetal brain;multiple sclerosis lesions;placenta;fibroblast;ovary (tumor);endothelial;parathyroid gland (tumor);endometrium (tumor);thyroid;retina;T cells (Jurkat cell line);colon;brain;muscle;fetal lung;heart 755821 Q12877 Nuclear (By similarity). "Nuclear factor erythroid 2 related factor 1 (NF-E2 related factor 1)(NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1)(Transcription factor 11) (Transcription factor HBZ17) (Transcr" "ACTIVATES ERYTHROID-SPECIFIC, GLOBIN GENE EXPRESSION." "Activator, DNA-binding, Nuclear protein, Transcription regulation" 94310069 GRID- 1-R9C1 2 1 a 8
10 "ESTs, Highly similar to KROS_HUMAN PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS PRECURSOR [H.sapiens]" ROS1 N79051 126700 306813 GRID- 1-R10C1 2 1 a 6
11 v-akt murine thymoma viral oncogene homolog 1 AKT1 W77811 71816 207 14q32.32 ovary (tumor);fetal liver/spleen;fetal heart;uterus (pregnant);brain--cerebellum;embryo (12 week);brain;colon;placenta;adipose--white;breast;infant brain;B-Cell;brain--hippocampus;heart;embryo (9 week);endothelial;adrenal gland (tumor);adipose tissue;muscle;T cells (Jurkat cell line);melanocyte 345839 P31749 CYTOPLASMIC AND NUCLEAR AFTER ACTIVATION BY INTEGRIN-LINKED PROTEIN KINASE 1 (ILK1). RAC-alpha serine/threonine kinase (EC 2.7.1.-) (RAC-PK-alpha)(Protein kinase B) (PKB) (C-AKT). GENERAL PROTEIN KINASE CAPABLE OF PHOSPHORYLATING SEVERAL KNOWN PROTEINS. "ATP-binding, Nuclear protein, Phosphorylation, Serine/threonine-protein kinase, Transferase" 98409636 GRID- 1-R11C1 2 1 a 4
12 vasodilator-stimulated phosphoprotein VASP AA410429 93183 7408 19q13.2-q13.3 B-Cell;uterus (pregnant);breast;pancreas (tumor);fetal liver/spleen;colon;T cells (Jurkat cell line);placenta;embryo (12 week);skin (tumor) 753418 GRID- 1-R12C1 2 1 a 2
13 myogenin (myogenic factor 4) p100 AA017382 2830 4656 1q31-q41 fetal skeletal muscle;retina 361048 P15173 Nuclear. Myogenin (Myogenic factor MYF-4). INVOLVED IN MUSCLE DIFFERENTIATION (MYOGENIC FACTOR). INDUCES FIBROBLASTS TO DIFFERENTIATE INTO MYOBLASTS. PROBABLE SEQUENCE SPECIFIC DNA-BINDING PROTEIN. "Developmental protein, Differentiation, DNA-binding, Myogenesis, Nuclear protein" 90059960 GRID- 1-R1C2 2 2 c 12
14 "protein kinase, AMP-activated, gamma 1 non-catalytic subunit" PRKAG1 AA070381 3136 5571 12q12-q14 "infant brain;B-Cell;pancreas (tumor);parathyroid gland (tumor);small intestine;retina;infant adrenal gland;gall bladder;melanocyte;heart;breast;placenta;colon (carcinoma, cell line Caco-2);adrenal gland (tumor);fetal heart;T-cell lymphoma;brain" 531028 P54619 "5'-AMP-activated protein kinase, gamma-1 subunit (AMPK gamma-1 chain)(AMPKg)." AMPK IS RESPONSIBLE FOR THE REGULATION OF FATTY ACID SYNTHESIS BY PHOSPHORYLATION OF ACETYL-COA CARBOXYLASE. ALSO REGULATES CHOLESTEROL SYNTHESIS VIA PHOSPHORYLATION AND INACTIVATION OF HYDROXYMETHYLGLUTARYL-COA REDUCTASE AND HORMONE- SENSITIVE LIPASE. THIS IS A REGULATORY SUBUNIT. "CBS domain, Fatty acid biosynthesis, Repeat" 96224074 GRID- 1-R2C2 2 2 c 10
15 "nuclear protein, marker for differentiated aortic smooth muscle and down-regulated with vascular injury" APEG1 R25020 21639 10290 2q36.1 infant brain;T cells (Jurkat cell line);fetal lung 35077 Q15772 Nuclear. Aortic preferentially expressed protein 1 (APEG-1). MAY HAVE A ROLE IN REGULATING THE GROWTH AND DIFFERENTIATION OF ARTERIAL SMOOTH MUSCLE CELLS. "Immunoglobulin domain, Nuclear protein" 96291890 GRID- 1-R3C2 2 2 c 8
16 mitogen-activated protein kinase 7 MAPK7 H39192 3080 5598 17p11.2 placenta;uterus (pregnant);infant brain;fetal brain;brain;colon 175123 Q16634 Mitogen-activated protein kinase 7 (EC 2.7.1.-) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase). MEK5 AND ERK5 INTERACT SPECIFICALLY WITH ONE ANOTHER AND NOT WITH MEK1/ERK1 OR MEK2/ERK2 PATHWAYS. "ATP-binding, Cell cycle, Phosphorylation, Serine/threonine-protein kinase, Transferase" 95374539 GRID- 1-R4C2 2 2 c 6
17 "tumor protein p53-binding protein, 2" TP53BP2 H69153 44585 7159 1q42.1 fetal liver/spleen;infant brain;breast;fetal spleen;parathyroid gland (tumor);fetal heart;T cells (Jurkat cell line);endometrium (tumor);placenta;melanocyte;uterus (pregnant) 212198 Q12892 "CYTOPLASMIC, IN A PUNCTATE GRANULAR/VESICULAR PATTERN." Tumor suppressor p53-binding protein 2 (p53-binding protein 2) (53BP2)(Bcl2-binding protein) (Bbp). IMPEDES CELL CYCLE PROGRESSION AT G2/M. "3D-structure, ANK repeat, Repeat, SH3 domain" 97035414 GRID- 1-R5C2 2 2 c 4
18 CREB binding protein (Rubinstein-Taybi syndrome) CREBBP AA023014 23598 1387 16p13.3 placenta;T cells (activated);fetal cochlea;testis;fetal heart;fetal liver/spleen;fibroblast;infant brain;brain;fetal lung;breast;colon;heart;fetal kidney;colorectal (tumor) 364329 O00147 Nuclear. CREB-binding protein. "MEDIATES CAMP-GENE REGULATION BY BINDING SPECIFICALLY TO PHOSPHORYLATED CREB PROTEIN. ACTING AS A COACTIVATOR, CBP AUGMENTS THE ACTIVITY OF PHOSPHORYLATED CREB TO ACTIVATE TRANSCRIPTION OF CAMP-RESPONSIVE GENES." "Activator, Bromodomain, Chromosomal translocation, Nuclear protein, Transcription regulation, Zinc-finger" 96376968 GRID- 1-R6C2 2 2 c 2
19 "protein kinase C, iota" PRKCI T57957 1904 5584 Xq21.3 B-Cell;HeLa (cell line);fetal spleen;fetal heart;fetal brain;brain 71622 P41743 "Protein kinase C, iota type (EC 2.7.1.-) (NPKC-iota)." "PKC IS ACTIVATED BY DIACYLGLYCEROL WHICH IN TURN PHOSPHORYLATES A RANGE OF CELLULAR PROTEINS. PKC ALSO SERVES AS THE RECEPTOR FOR PHORBOL ESTERS, A CLASS OF TUMOR PROMOTERS." "ATP-binding, Phorbol-ester binding, Serine/threonine-protein kinase, Transferase, Zinc" 95331807 GRID- 1-R7C2 2 1 c 12
20 "protein kinase, cAMP-dependent, catalytic, alpha" PRKACA W68141 77271 5566 19p13.1 fetal liver/spleen;breast;fetal heart;brain;melanocyte;multiple sclerosis lesions;colon;T cells (Jurkat cell line);muscle;amnion;eye;brain--cerebellum;pancreatic islets 342543 P17612 "cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.1.37)(PKA C-alpha)." "ATP-binding, cAMP, Multigene family, Myristate, Phosphorylation, Serine/threonine-protein kinase, Transferase" 88335571 GRID- 1-R8C2 2 1 c 10

Total number of rows: 1152

Table truncated, full table size 454 Kbytes.




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