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| Status |
Public on Jul 18, 2017 |
| Title |
Deletion of 11q in neuroblastomas drives sensitivity to PARP inhibition [SNP array] |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
|
| Summary |
SNP arrays were combined with next generation sequencing (NGS) to precisely define the deleted region in 17 primary 11q-loss neuroblastomas and identify allelic variants in genes relevant for neuroblastoma aetiology. We assessed PARP inhibitor olaparib in combination with other chemotherapy medications using both in vitro and in vivo models.
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| Overall design |
CytoScan HD arrays (Affymetrix) were performed according to the manufacturer's directions on DNA extracted from 17 neuroblastoma tumor samples and 7 neuroblastoma cell lines.
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| |
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| Contributor(s) |
Font de Mora J, Sanmartín E |
| Citation(s) |
28830922 |
| |
| Submission date |
Jul 17, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Jaime Font de Mora |
| E-mail(s) |
fontdemora@iislafe.es
|
| Organization name |
Instituto de Investigación Sanitaria La Fe
|
| Lab |
Cellular an Molecular Bioogy Laboratory
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| Street address |
Avenida Fernando Abril Martorell, 106; Torre A, 5-07
|
| City |
Valencia |
| ZIP/Postal code |
46026 |
| Country |
Spain |
| |
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| Platforms (1) |
| GPL16131 |
[CytoScanHD_Array] Affymetrix CytoScan HD Array |
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| Samples (24)
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| This SubSeries is part of SuperSeries: |
| GSE101990 |
Deletion of 11q in neuroblastomas drives sensitivity to PARP inhibition |
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| Relations |
| BioProject |
PRJNA394738 |
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