Genome variation profiling by high throughput sequencing
Summary
SNP arrays were combined with next generation sequencing (NGS) to precisely define the deleted region in 17 primary 11q-loss neuroblastomas and identify allelic variants in genes relevant for neuroblastoma aetiology. We assessed PARP inhibitor olaparib in combination with other chemotherapy medications using both in vitro and in vivo models.
Overall design
Next generation sequencing of genes relevant for neuroblastoma aetiology and cancer
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