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| Status |
Public on Aug 02, 2020 |
| Title |
Integrative analysis of hepatic microRNA and mRNA to identify potential biological pathways associated with monocrotaline-induced liver injury in mice |
| Platform organisms |
Mus musculus; Murid betaherpesvirus 1; Murid gammaherpesvirus 4 |
| Sample organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
Expression profiling by array
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| Summary |
In this study, the analysis of miRNA and mRNA expression profiles was used to identify the potential engaged biological signaling pathways involved in Monocrotaline-induced liver injury.
There were total 35 hepatic miRNAs differentially expressed in mice treated with Monocrotaline (both 270 mg/kg and 330 mg/kg)
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| Overall design |
[miRNA] In the study presented here, 9 liver samples from 3 groups (control group,270 mg/kg MCT group and 330mg/kg MCT group) were collected, each group contained 3 replicates, and were used to acquire expression profiles of a total of 1,177 unique miRNAs.
[mRNA] In the study presented here, 9 liver samples from 3 groups(control group,270 mg/kg MCT group and 330mg/kg MCT group)were collected, each group contained 3 replicates, and were used to acquire expression profiles of a total of 18,816 genes.
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| Contributor(s) |
Huang Z, Ji L |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Aug 02, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Zhenlin Huang |
| E-mail(s) |
zhenlin163@163.com
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| Organization name |
Shanghai University of Traditional Chinese Medicine
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| Department |
Institute of Chinese Materia Medica
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| Lab |
Shanghai Key Laboratory of Complex Prescription
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| Street address |
1200 Cailun Road, Zhangjiang High Tech Park
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| City |
Shanghai |
| State/province |
Shanghai |
| ZIP/Postal code |
201203 |
| Country |
China |
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| Platforms (2) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
| GPL23853 |
Exiqon miRCURY LNA microRNA Array,7th generation [miRBase v18] |
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| Samples (18)
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| GSM2728860 |
mice 4,2-1 (miRNA) |
| GSM2728861 |
mice 5,2-2 (miRNA) |
| GSM2728862 |
mice 6,2-3 (miRNA) |
| GSM2728863 |
mice 7,3-1 (miRNA) |
| GSM2728864 |
mice 8,3-2 (miRNA) |
| GSM2728865 |
mice 9,3-3 (miRNA) |
| GSM2728872 |
mice 1,1-1 (mRNA) |
| GSM2728873 |
mice 2,1-2 (mRNA) |
| GSM2728874 |
mice 3,1-3 (mRNA) |
| GSM2728875 |
mice 4,2-1 (mRNA) |
| GSM2728876 |
mice 5,2-2 (mRNA) |
| GSM2728877 |
mice 6,2-3 (mRNA) |
| GSM2728878 |
mice 7,3-1 (mRNA) |
| GSM2728879 |
mice 8,3-2 (mRNA) |
| GSM2728880 |
mice 9,3-3 (mRNA) |
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| Relations |
| BioProject |
PRJNA396854 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE102150_Foreground_Background_Normalized_CV_miRNA.txt.gz |
99.3 Kb |
(ftp)(http) |
TXT |
| GSE102150_RAW.tar |
28.3 Mb |
(http)(custom) |
TAR (of GPR, TXT) |
| Processed data included within Sample table |
| Processed data are available on Series record |
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