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Series GSE104192 Query DataSets for GSE104192
Status Public on May 01, 2018
Title Expression profiling from mouse embryonic stem cells (ESCs)
Organism Mus musculus
Experiment type Expression profiling by array
Summary Sin3a, a known master scaffold, provides unique contact surfaces for interaction with particular accessory proteins to repress the transcription of specific genes. Surprisingly, our results also suggest that Sin3a has a role in transcriptional activation.
We compared gene expression differences between Sin3a knockdown and control ESCs with mouse gene expression microarrays and identified an approximately equal distribution of up- and down-regulated genes following Sin3a knockdown in mouse ESCs. We propose that Sin3a collaborates with Tet1 to demethylate adjacent genomic regions and, ultimately, facilitates actively transcribed gene expression in mouse ESCs.
 
Overall design Control (shCtrl) or Sin3a knockdown (shSin3a-1) mouse ESCs were used.
 
Contributor(s) Zhu F, Zhu Q, Kang J
Citation(s) 29733394
Submission date Sep 25, 2017
Last update date Jul 25, 2021
Contact name Qianshu Zhu
E-mail(s) zhuqianshu@tongji.edu.cn
Organization name Tongji University
Department School of Life Science and Technology
Street address Siping Road
City Shanghai
State/province Shanghai
ZIP/Postal code 270000
Country China
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (2)
GSM2791558 E14_shCtrl
GSM2791559 E14_shSin3a-1
Relations
BioProject PRJNA412002

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE104192_RAW.tar 8.1 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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