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Series GSE104443 Query DataSets for GSE104443
Status Public on Sep 30, 2017
Title Regulation of gene expression by FOXC1 in mouse mammary epithelial cells.
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The FOXC1 transcription factor plays a critical role in basal-like breast cancer development and metastasis. However, it is not clear whether its overexpression alters normal mammary development and mammary cell function in vivo. We used MMTV-FOXC1 transgenic mice to adddress this question. In association with the lobuloalveologenesis and lactation-related phenotype in the transgenic mice, we also found marked gene expression changes in mammary epithelial cells of the transgenic mice compared with wildtype mice at the lactation stage. Differentially expressed genes identified by RNA-Seq analysis include those involved in fatty acid metabolism, PPAR, cytokine, chemokine, inflammation, and NF-κB signaling. These data suggest that FOXC1 is an important regulator of mammary cell function.
Overall design Comparison of gene expression profiles in mammamry epithelial cells from MMTV-FOXC1 transgenic and wildtype mice at the lactation stage.
Contributor(s) Gao B, Deng N, Cui X
Citation(s) 29070831
Submission date Sep 29, 2017
Last update date May 15, 2019
Contact name Xiaojiang Cui
Phone 3104237437
Organization name Cedars Sinai Medical Center
Department Surgery Dept
Lab Breast Cancer Research Lab
Street address 3884 Fredonia Dr#F
City Los Angeles
State/province CA
ZIP/Postal code 90068
Country USA
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (6)
GSM2800627 Wt1-L2
GSM2800628 Wt2-L2
GSM2800629 Wt3-L2
BioProject PRJNA412641
SRA SRP119154

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE104443_Tg_vs_Wt.xlsx.xlsx 3.6 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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