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Series GSE106118 Query DataSets for GSE106118
Status Public on Jan 25, 2019
Title Single-Cell Transcriptome Analysis Maps the Developmental Track of the Human Heart
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The heart is the central organ of the circulatory system, and its proper development is vital for maintaining human life. Here we used single-cell RNA-sequencing to profile the gene expression landscapes of ~4,000 cardiac cells from human embryos and identified four major types of cells: cardiomyocytes (CMs), cardiac fibroblasts, endothelial cells (EC) and valvar interstitial cells (VICs). During heart development, atrial and ventricular CMs acquired distinct features early in development. Furthermore, both CMs and fibroblasts show stepwise changes in gene expression. As development proceeds, VICs might be involved in the remodeling phase, and ECs display location-specific characteristics. Finally, we compared gene expression profiles between human and mouse and identified a serial of unique features of human heart development. Our study lays the groundwork for elucidating the mechanisms of in vivo human cardiac development and provides potential clues to understand cardiac regeneration.
The gene expression pattern of our data can be easily viewed and navigated at
Overall design single cell RNA seq data set 1: 77 samples
single cell RNA seq data set 2: 21 samples
Contributor(s) Cui Y, Zheng Y, Liu X, Yan L, Fan X, Yong J, Hu Y, Dong J, Li Q, Wu X, Gao S, Li J, Wen L, Qiao J, Tang F
Citation(s) 30759401
Submission date Oct 24, 2017
Last update date Oct 19, 2021
Contact name Yuxuan Zheng
Organization name Fudan University
Street address 825 Zhangheng Rd.
City Shanghai
ZIP/Postal code 201203
Country China
Platforms (1)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (98)
GSM2829942 HE6W_LA
GSM2829943 HE6W_LV
GSM2829944 HE6W_RA
BioProject PRJNA415637
SRA SRP121350

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE106118_RAW.tar 65.3 Mb (http)(custom) TAR (of TXT)
GSE106118_UMI_count_merge.txt.gz 26.0 Mb (ftp)(http) TXT
GSE106118_barcode_information.txt.gz 19.9 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Processed data provided as supplementary file
Raw data are available in SRA

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