|
| Status |
Public on Dec 16, 2017 |
| Title |
Acute treatment with kynurenic acid in inguinal primary adipocytes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Tryptophan-kynurenine metabolism plays an important role in the pathogenesis of several psychiatric diseases but its physiological function in peripheral tissues remains unclear. Physical exercise training activates a biochemical pathway in skeletal muscle that protects from neuroinflammation and, as a byproduct, leads to kynurenic acid accumulation in the periphery. We therefore investigated the effects of kynurenic acid in murine white adipose tissue.
We used microarrays to detail global programme of gene expression underlying Kynurenic acid mediated effects on inguinal primary adipocytes.
|
| |
|
| Overall design |
Fully differentiated inguinal primary fat cells were treated for 12h with 50μM of kynurenic acid or PBS (control), in triplicate. RNA was extracted and used for global gene expression analyses.
|
| |
|
| Contributor(s) |
Agudelo LZ, Ruas JL |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 15, 2017 |
| Last update date |
Feb 21, 2018 |
| Contact name |
Leandro Z. Agudelo |
| E-mail(s) |
leandro.agudelo@ki.se
|
| Phone |
+46 7 07 45 7424
|
| Organization name |
Karolinska Institutet
|
| Department |
Physiology and Pharmacology
|
| Lab |
M&CEP
|
| Street address |
von eulers väg 8, plan 3
|
| City |
Stockholm |
| State/province |
Stockholm |
| ZIP/Postal code |
17177 |
| Country |
Sweden |
| |
|
| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA422606 |
Less...
More...