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Series GSE108258 Query DataSets for GSE108258
Status Public on Dec 19, 2018
Title The impact of Unc45A silencing on gene expression in the human breast cancer Hs578T (ATCC HTB-126) cell line
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The co-chaperone Unc45A is essential for cancer cell growth. We show that Unc45A, a cytoplasmic protein in normal cells, becomes nuclear in cancer cells. We used Microarray to determine the impact of UNC45A on gene expression. We found that Unc45A unctions as a co-activator of the glucocorticoid receptor. In this capacity, it differentially promotes expression of the mitotic kinase NEK7 and other genes possibly through regulation of nuclear receptors.
Overall design Human breast triple negative Hs578T cancer cells were transfected with siRNA against Unc45A or non-targeting siRNA control.
Contributor(s) Chadli A
Citation(s) 30737284
Submission date Dec 19, 2017
Last update date Apr 22, 2019
Contact name Ahmed Chadli
Phone 7067214661
Organization name Augusta University
Department Cancer Center
Street address 1410 Laney Walker BLVD
City Augusta
State/province GA
ZIP/Postal code 30912
Country USA
Platforms (1)
GPL6244 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Samples (4)
GSM2893776 Control cells 1
GSM2893777 Control cells 2
GSM2893778 Unc45A SiRNA 1
BioProject PRJNA422991

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Supplementary file Size Download File type/resource
GSE108258_RAW.tar 17.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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