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Series GSE108311 Query DataSets for GSE108311
Status Public on Dec 31, 2019
Title A mosaic renal myeloid subtype linked to immune escape correlates with poor patient survival in clear cell renal cell carcinoma [in vitro]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Mononuclear phagocytes moderate tissue repair, immune activation and tolerance. In the renal tubulo-interstitium, specialized DCs help maintain homeostasis and protect tubuli from immune injury. Human renal cell carcinoma is immunogenic; yet immunotherapies that target T-cell dysfunction show limited clinical efficacy suggesting additional mechanisms of immunoinhibition. We previously described “enriched-in-renal cell carcinoma” (erc)DCs. In tumor tissue, they are found in tight contact with T cells which are dysfunctional. Here we describe that ercDCs exhibit a distinct polarization state imparted by tissue-specific signals characteristic for ccRCC and renal tissue homeostasis. The resulting mosaic transcript signature includes features associated with host defense activity, angiogenesis/invasion and T-cell inhibition. An ercDC-specific profile was predictive for patient survival and suggests potential therapeutic targets for improved immunotherapy.
 
Overall design Pooled RNA isolated from in vitro cultured cells.
 
Contributor(s) Brech D, Straub T, Kokolakis E, Irmler M, Beckers J, Buettner F, Schaeffeler E, Winter S, Schwab M, Nelson PJ, Noessner E
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Submission date Dec 19, 2017
Last update date Jan 01, 2020
Contact name Tobias Straub
E-mail(s) tstraub@med.uni-muenchen.de
Organization name LMU Munich
Department Biomedical Center, Bioinformatics
Street address Großhadener Str. 9
City Martinsried
ZIP/Postal code 82152
Country Germany
 
Platforms (1)
GPL6244 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Samples (9)
GSM2895273 M1-MP_in vitro_1
GSM2895274 M1-MP_in vitro_2
GSM2895275 M1-MP_in vitro_3
This SubSeries is part of SuperSeries:
GSE108312 A mosaic renal myeloid subtype linked to immune escape correlates with poor patient survival in clear cell renal cell carcinoma
Relations
BioProject PRJNA423142

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE108311_RAW.tar 34.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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