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Series GSE109883 Query DataSets for GSE109883
Status Public on May 01, 2018
Title Global gene expression profiling reveal distinct molecular profiles between p53-sensitive and p53-resistant T-cell lymphomas
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary TP53 mutations occur in approximately 50% of all human tumors with increased frequency in aggressive cancers that are notoriously difficult to treat. Additionally, p53 missense mutations are remarkably predictive of refractoriness to chemo/radiotherapy in various malignancies. These observations have led to the development of mutant-p53 targeting agents that restore p53 function. An important unknown is which p53-mutant tumors will respond to p53 reactivation-based therapies. Here we found a heterogeneous impact on therapeutic response to p53 restoration, suggesting it will unlikely be effective as a single therapy.
The goal of the study was to identify the pathways conferring resistance or sensitivity to genetic p53 restoration in tumors with a p53 missense mutaiton
Results:We sequenced the transcriptome of tumors that were sensitive or resistant to p53 restoration and found that TNF signaling was activated in p53-sensitive tumors.
Overall design 12 independent biological samples were analyzed to compare tumors that were sensitive (n=8) or resistant (n=4) to genetic p53 restoration
Contributor(s) Lozano G, Liu B, Larsson C
Citation(s) 29440484
Submission date Jan 30, 2018
Last update date Feb 11, 2019
Contact name Bin Liu
Organization name University of Texas MD Anderson Cancer Center
Department Epigenetics and Molecular Carcinogenesis
Lab bioinformatics
Street address 1808 Park Road 1C
City Smithville
State/province TX
ZIP/Postal code 78957
Country USA
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (12)
GSM2973224 X1397.T
GSM2973225 X1442.T
GSM2973226 X1493.T
BioProject PRJNA432239
SRA SRP131795

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Supplementary file Size Download File type/resource
GSE109883_samples_updated.count.txt.gz 568.1 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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