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| Status |
Public on Feb 20, 2020 |
| Title |
Evaluation of CNAs in multiple myeloma tumors from Vk*MYC mice |
| Organism |
Mus musculus |
| Experiment type |
Genome variation profiling by array
|
| Summary |
Myeloma tumors arose in Vk*MYC mice share copy number abnormalities with multiple myeloma tumors from human patients
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| |
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| Overall design |
Genomic DNA from CD138+ magnetically selected myeloma cells harvested from aged Vk*MYC mice (original tumors) or from C57BL/6 WT mice engrafted with original Vk*MYC myeloma tumors (recipients) was hybridized to Agilent mouse whole genome 244K CGH array
CL= cell line
OT=original tumor
R=recipient
BN= bortezomib naïve
BR=bortezomib resistant
MM=multiple myeloma
EMM= extramedullary MM
NPC=normal plasma cell
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| |
|
| Contributor(s) |
Chesi M, Braggio E, Bergsagel PL |
| Citation(s) |
32954360 |
|
Marta Chesi, Caleb K Stein, Victoria M Garbitt, Meaghen E Sharik, Yan W Asmann, Matteo Bergsagel, Daniel L Riggs, Seth J Welsh, Erin W Meermeier, Shaji K Kumar, Esteban Braggio, and P Leif Bergsagel. Monosomic Loss of MIR15A/MIR16-1 Is a Driver of Multiple Myeloma Proliferation and Disease Progression. Blood Cancer Discov 2020. doi:10.1158/0008-5472.BCD-19-0068
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| |
| Submission date |
Feb 21, 2018 |
| Last update date |
Sep 28, 2020 |
| Contact name |
Marta Chesi |
| E-mail(s) |
chesi.marta@mayo.edu
|
| Organization name |
Mayo Clinic
|
| Street address |
13400 E Shea Blvd
|
| City |
Scottsdale |
| State/province |
AZ |
| ZIP/Postal code |
85259 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL4092 |
Agilent-014695 Mouse Genome CGH Microarray 244A (G4415A) (Feature Number version) |
|
| Samples (26)
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| This SubSeries is part of SuperSeries: |
| GSE111922 |
Multiple myeloma tumors from Vk*MYC mice |
|
| Relations |
| BioProject |
PRJNA435404 |
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