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Series GSE111600 Query DataSets for GSE111600
Status Public on Nov 02, 2018
Title Exploiting Mouse Models to Understand Female Hypersensitivity to Cocaine
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Male mice, female mice, ovariectomized female mice given placebo pellets, and ovariectomized female mice given extradiol pellets were treated with experimenter-administered saline or cocaine for 7 days, and behaviorally monitored. After a 28 day withdrawal period, RNA samples were prepared from nucleus accumbens and subjected to RNA-Seq, followed by differential expression analyses using Cuffdiff, Limma and DESeq2. Selected transcripts were further investigated using quantitative polymerase chain reaction.
Overall design After surgeries and non-operated controls, mice were administered saline or cocaine, and behaviorally analyzed. After withdrawal from drugs, nucleus accumbens RNA was used for RNA-Seq and qPCR analyses.
Contributor(s) Mains RE, Rheaume BA
Citation(s) 30746506
Submission date Mar 08, 2018
Last update date Mar 25, 2019
Contact name Richard E Mains
Phone 8606798894
Organization name University of Connecticut Health Center
Department Neuroscience
Street address 263 Farmington Ave, Neuroscience Dept., Neuroscience Dept.
City Farmington
State/province CT
ZIP/Postal code 06030-3401
Country USA
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (40)
GSM3034760 Male_saline_61
GSM3034761 Male_saline_62
GSM3034762 Male_saline_63
BioProject PRJNA437488
SRA SRP134204

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Supplementary file Size Download File type/resource
GSE111600_FPKM_AllMice_AllTranscripts.xlsx 10.7 Mb (ftp)(http) XLSX
GSE111600_Reads-Saline_Cocaine.pdf 93.2 Kb (ftp)(http) PDF
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Raw data are available in SRA
Processed data are available on Series record

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