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Series GSE111796 Query DataSets for GSE111796
Status Public on Mar 14, 2018
Title Nuclear Receptor NR2F6 as an Alternative Cancer Immune Checkpoint in the T Cell Compartment
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Analyzing mouse tumor models in vivo, human T cells ex vivo and human lung cancer samples, we provide direct evidence that NR2F6 acts as novel immune checkpoint. Genetic ablation of Nr2f6, particularly in combination with blockade of the established PD-L1 cancer immune checkpoint, efficiently delayed tumor progression and improved survival in experimental mouse models. The target genes deregulated in intratumoral T lymphocytes upon genetic ablation of Nr2f6 alone or together with PD-L1 blockade, revealed multiple advantageous transcriptional alterations for effective tumor rejection. In keeping with the above observation, acute Nr2f6 silencing in both mouse and human T cells induced hyper-responsiveness that established a non-redundant T cell-inhibitory function of NR2F6.
Analyzing mouse tumor models in vivo, human T cells ex vivo and human lung cancer samples,
 
Overall design TILs derived from wild-type and Nr2f6-/- tumor-bearing mice collected at d14 after B16-OVA tumor cell injection. and subjected to detailed analysis, including FACS sequencing and RNA sequencing
 
Contributor(s) Klepsch V, Hermann-Kleiter N, Do-Dinh P, Jakic B, Offermann A, Efremova M, Sopper S, Rieder D, Krogsdam A, Gamerith G, Perner S, Tzankov A, Trajanoski Z, Wolf D, Baier G
Citation(s) 29670099
Submission date Mar 13, 2018
Last update date Feb 11, 2019
Contact name Dietmar Rieder
E-mail(s) dietmar.rieder@i-med.ac.at
Phone +43512900371402
Organization name Innsbruck Medical University
Department Biocenter
Lab Division of Bioinformatics
Street address Innrain 80
City Innsbruck
ZIP/Postal code 6020
Country Austria
 
Platforms (1)
GPL18635 Ion Torrent Proton (Mus musculus)
Samples (18)
GSM3039856 rep1_Nr2f6_IgG2b [Lexogen_28]
GSM3039857 rep2_Nr2f6_IgG2b [Lexogen_29]
GSM3039858 rep3_Nr2f6_IgG2b [Lexogen_30]
Relations
BioProject PRJNA438152
SRA SRP135514

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Supplementary file Size Download File type/resource
GSE111796_normalized_counts_therapy.txt.gz 1.3 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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