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Series GSE112984 Query DataSets for GSE112984
Status Public on Dec 25, 2018
Title Characterization of myocardial B cells in naïve hearts, acutely injured hearts and acutely injured hearts of mice treated with Pirfenidone
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Myocardial CD19+CD11b+ and CD19+CD11b- cells were FACS sorted from transgenic mice expressing the Diphtheria Toxin (DT) receptor under the myocardial specific MLC2v promoter. Cells were sorted from hearts of mice not exposed to DT (naïve hearts), from the hearts of animals treated with DT 4 days prior to the experiment (DTR) and from the hearts of mice exposed to DT and fed chow enriched with the anti-inflammatory/anti-fibrotic drug Pirfenidone (0.5% in powdered chow, PFD)
 
Overall design Cells sorted from naïve hearts were compared to cells sorted from DTR injured hearts and to cells sorted from the hearts of DTR injured animals treated with Pirfenidone
 
Contributor(s) Adamo L, Matkovich SJ, Mann DL
Citation(s) 29875326
Submission date Apr 11, 2018
Last update date Feb 11, 2019
Contact name Scot J Matkovich
E-mail(s) smatkovich@gmail.com
Organization name Washington University School of Medicine
Department Center for Cardiovascular Research
Street address 660 S Euclid Ave, box 8086
City St. Louis
State/province MO
ZIP/Postal code 63110
Country USA
 
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (34)
GSM3092647 set1, Myocardial DTR transgenic, CD19+CD11b-, DT-treated, 10
GSM3092648 set1, Myocardial DTR transgenic, CD19+CD11b+, DT-treated, 11
GSM3092649 set1, Myocardial DTR transgenic, CD19+CD11b-, DT-treated, 12
Relations
BioProject PRJNA449679
SRA SRP139558

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE112984_depth-normalized_batch-corrected_cpm-filtered_HTSeq-data.txt.gz 926.4 Kb (ftp)(http) TXT
GSE112984_unprocessed_HTSeq-data.txt.gz 1.9 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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