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Series GSE113135 Query DataSets for GSE113135
Status Public on Jun 07, 2023
Title The effect of diet and breed on global gene expression profiles of animals divergent for RFI
Organism Bos taurus
Experiment type Expression profiling by high throughput sequencing
Summary The selection of cattle with high feed efficiency is of paramount importance with regard to reducing feed costs in the beef industry. Developing predictive biological markers specifically for improved feed efficiency is an attractive alternative to direct measurement on large numbers of animals.Evidence is provided that, effects of RFI on gene expression in muscle of beef cattle are not consistent across breed type or dietary phase. These novel observations challenge the practicality of selecting and breeding for low RFI animals across different diets and stages of development. Perhaps, future research should be directed at utilising different diets to harness the full genetic potential of animal based on breed or stage of maturity. Further to this, evidence is provided from our own work and that of others that less efficient HF steers consuming zero grazed grass are under increased stress as demonstrated by an upregulation of immune function in these animals.
Overall design Residual feed intake was calculated in in Charolais (CH) and Holstein Freisan (HF) under ad libitum feeding conditions aross varying diets, which were subsequently ranked, within breed and diet, as high (n=12) or low (n=12) residual feed intake. RNA sequencing was performed on liver and skeletall muscle biopsies from high and low residual feed intake animals in order to identify differentially expressed genes that may be associated with this trait.
Contributor(s) Mckenna C, Kenny DA, Porter RK, Waters S, Blackshields G
Citation(s) 37270611
Submission date Apr 13, 2018
Last update date Jun 08, 2023
Contact name Clare Mckenna
Organization name Teagasc
Department Animal Bioscience
Street address Dunsaney
City Meath
ZIP/Postal code Co Meath
Country Ireland
Platforms (1)
GPL19172 Illumina HiSeq 2500 (Bos taurus)
Samples (111)
GSM3097787 1078P1M
GSM3097788 1100P1M
GSM3097789 1100P3M
BioProject PRJNA450105
SRA SRP139962

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Supplementary file Size Download File type/resource
GSE113135_RAW.tar 14.4 Mb (http)(custom) TAR (of TAB)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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