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Series GSE113570 Query DataSets for GSE113570
Status Public on Feb 28, 2019
Title Exosomal lncRNA sequencing in Atorvastatin treated and non-treated MSC-derived exosomes
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
Summary In order to investigate the molecular mechanisms underlying the further enhancement of Atorvastatin pretreated MSC-derived exosomes (MSCATV-Exo) in cardiac protection, we performed lncRNA sequencing on exosomes secreted from ATV pretreated MSCs and non treated MSCs to identify differentially expressed lncRNA. We found that 450 lncRNAs were identified to be upregulated and 1332 lncRNAs downregulated (over 1.5 fold change) in MSCATV-Exo compared to MSC-Exo.
 
Overall design Two samples were processed for each kind of exosomes that derived from normal MSCs and ATV pretreating MSCs (MSC-Exo and MSCATV-Exo). MSCATV-Exo was isolated from conditioned medium of MSCs pretreated by 1╬╝mol/L of ATV for 24 hours. RNA isolated from exosomes were analyzed using Illumina HiSeq 2500.
 
Contributor(s) Huang P, Yang Y
Citation(s) 31119268
Submission date Apr 24, 2018
Last update date Jun 28, 2021
Contact name Peisen Huang
E-mail(s) hps0814@qq.com
Phone 4043844891
Organization name Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Street address No.167 Bei Li Shi Road, Xicheng District
City Beijing
State/province Beijing
ZIP/Postal code 100037
Country China
 
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (4)
GSM3109212 MSC-Exo-1: exosomes derived from normal MSCs
GSM3109213 MSC-Exo-2: exosomes derived from normal MSCs
GSM3109214 MSCATV-Exo-1: exosomes derived from ATV pretreated MSCs
Relations
BioProject PRJNA453127
SRA SRP142436

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE113570_MSC-Exo_vs_MSCATV-Exo.Differential_ncRNA_analysis_results.txt.gz 78.4 Kb (ftp)(http) TXT
GSE113570_MSC-Exo_vs_MSCATV-Exo.all.gene.txt.gz 2.3 Mb (ftp)(http) TXT
GSE113570_MSC-Exo_vs_MSCATV-Exo.all.ncRNA.txt.gz 712.8 Kb (ftp)(http) TXT
GSE113570_gene_exp.txt.gz 2.1 Mb (ftp)(http) TXT
GSE113570_ncRNA_exp.txt.gz 588.8 Kb (ftp)(http) TXT
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Processed data are available on Series record

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